SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF NOVEL 2-METHYL-1-OXACEPHALOSPORINS

被引：1

作者：

OKONOGI, T

SHIBAHARA, S

MURAI, Y

YOSHIDA, T

INOUYE, S

KONDO, S

CHRISTENSEN, BG

机构：

[1] INST MICROBIAL CHEM,SHINAGAWA KU,TOKYO 141,JAPAN

[2] MERCK SHARP & DOHME LTD,RAHWAY,NJ 07065

来源：

JOURNAL OF ANTIBIOTICS | 1990年 / 43卷 / 04期

关键词：

D O I：

10.7164/antibiotics.43.357

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

New 2-methyl-1-oxacephem compounds having 2-(2-aminothiazol-4-yl)-2-(alkoxyimino)acetamido substituents at C-7 and various C-3 side chains were synthesized starting from (3R, 4S)-phenyloxazolinoazetidinone (8). Introduction of the 2β-methyl group into the 1 -oxacephem nucleus increased the stability to β-lactamases. OCP-9-176 (7b) having the (l-methylpyridinium-4-yl)thiomethyl group at C-3 showed potent antibacterial activity and a broad spectrum. © 1990, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.

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页码：357 / 371

页数：15

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