SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF NOVEL 2-METHYL-1-OXACEPHALOSPORINS

被引:1
作者
OKONOGI, T
SHIBAHARA, S
MURAI, Y
YOSHIDA, T
INOUYE, S
KONDO, S
CHRISTENSEN, BG
机构
[1] INST MICROBIAL CHEM,SHINAGAWA KU,TOKYO 141,JAPAN
[2] MERCK SHARP & DOHME LTD,RAHWAY,NJ 07065
关键词
D O I
10.7164/antibiotics.43.357
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
New 2-methyl-1-oxacephem compounds having 2-(2-aminothiazol-4-yl)-2-(alkoxyimino)acetamido substituents at C-7 and various C-3 side chains were synthesized starting from (3R, 4S)-phenyloxazolinoazetidinone (8). Introduction of the 2β-methyl group into the 1 -oxacephem nucleus increased the stability to β-lactamases. OCP-9-176 (7b) having the (l-methylpyridinium-4-yl)thiomethyl group at C-3 showed potent antibacterial activity and a broad spectrum. © 1990, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.
引用
收藏
页码:357 / 371
页数:15
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