2-AMINOOXAZOLINES .1. CRYSTAL AND MOLECULAR-STRUCTURE OF 5-(1-ARYL-4-PIPERAZINO)METHYL-SUBSTITUTED DERIVATIVES WITH ANTIDEPRESSANT ACTIVITY

被引:15
作者
JARRY, C [1 ]
BOSC, JJ [1 ]
OUHABI, J [1 ]
CARPY, A [1 ]
机构
[1] UNIV BORDEAUX 2,FAC SCI PHARMACEUT,CNRS,URA 50,F-33076 BORDEAUX,FRANCE
关键词
D O I
10.1002/ardp.19903230306
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
The structure of two 5‐(1‐aryl‐4‐piperazino)methyl‐2‐aminooxazolines were determined by X‐ray crystallography. An amino form is preponderant in a free base whereas an imino form is preponderant in a salt. The molecular conformations were studied by molecular mechanics. Copyright © 1990 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim
引用
收藏
页码:157 / 161
页数:5
相关论文
共 9 条
[1]  
BOURIN M, 1988, ARZNEIMITTEL-FORSCH, V38-1, P666
[2]  
Cromer D.T, 1974, INT TABLES XRAY CRYS, VIV
[3]   OXAZOLINES - THEIR PREPARATION, REACTIONS, AND APPLICATIONS [J].
FRUMP, JA .
CHEMICAL REVIEWS, 1971, 71 (05) :483-&
[4]  
JARRY C, 1986, EUR J MED CHEM, V21, P138
[5]  
JARRY C, 1985, ANN PHARM FR, V43, P183
[6]  
MAIN P, 1980, MULTAN SYSTEM COMPUT
[7]   COHERENT X-RAY SCATTERING FOR HYDROGEN ATOM IN HYDROGEN MOLECULE [J].
STEWART, RF ;
DAVIDSON, ER ;
SIMPSON, WT .
JOURNAL OF CHEMICAL PHYSICS, 1965, 42 (09) :3175-&
[8]  
1987, ANN DRUG DATA REP, V9, P658
[9]  
1988, Patent No. 6253