DNA Methylation and Colorectal Cancer

被引：57

作者：

Ashktorab, Hassan ^{[1
,2
]}

Brim, Hassan ^{[3
]}

机构：

[1] Howard Univ, Dept Med, Coll Med, Washington, DC 20059 USA

[2] Howard Univ, Coll Med, Canc Ctr, Washington, DC USA

[3] Howard Univ, Coll Med, Dept Pathol, Washington, DC USA

来源：

CURRENT COLORECTAL CANCER REPORTS | 2014年 / 10卷 / 04期

关键词：

DNAmethylation; Colon cancer;

D O I：

10.1007/s11888-014-0245-2

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Colorectal cancer (CRC) is one of the major cancers in the world and the second death-causing cancer in the USA. CRC development involves genetic and epigenetic alterations. Changes in DNA methylation status are believed to be involved at different stages of CRC. Promoter silencing via DNA methylation and hypomethylation of oncogenes alters gene expression and can be used as a tool for the early detection of colonic lesions. DNA methylation use as a diagnostic and prognostic marker has been described for many cancers including CRC. CpG island methylator phenotype (CIMP) is one of the underlying CRC mechanisms. This review aims to define methylation signatures in CRC. The analysis of DNA methylation profile in combination with the pathological diagnosis would be useful in predicting CRC tumor evolution and their prognostic behavior.

引用

页码：425 / 430

页数：6

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