EPSTEIN-BARR VIRUS-ASSOCIATED LARGE GRANULAR LYMPHOCYTE LEUKEMIA WITH CUTANEOUS INFILTRATION

被引：31

作者：

ASADA, H ^{[1
]}

OKADA, N ^{[1
]}

TEI, H ^{[1
]}

YAMAMURA, T ^{[1
]}

HASHIMOTO, K ^{[1
]}

KONDO, K ^{[1
]}

YAMANISHI, K ^{[1
]}

YOSHIKAWA, K ^{[1
]}

机构：

[1] OSAKA UNIV,MICROBIAL DIS RES INST,DEPT VIROL,SUITA,OSAKA 565,JAPAN

来源：

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY | 1994年 / 31卷 / 02期

关键词：

D O I：

10.1016/S0190-9622(94)70157-1

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

A 36-year-old man had a high titer of antibody to Epstein-Barr virus (EBV) and recurrent necrotizing papules and nodules on his face and oral mucosa. The disease was diagnosed as CD3(+)4(-) 8(+) large granular lymphocyte leukemia of T-cell origin. Southern blot analysis demonstrated that EBV DNA was present in CD8(+) lymphocytes; EBV antigens were also observed in these lymphocytes. These findings demonstrated that EBV latently infected the leukemic cells and may have played a role in the pathogenesis of this disease. This is the first report of an association between EBV and large granular lymphocyte leukemia of T-cell origin.

引用

页码：251 / 255

页数：5

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