EXPRESSION OF INTERLEUKIN-10 ACTIVITY BY EPSTEIN-BARR-VIRUS PROTEIN BCRF1

被引：469

作者：

HSU, DH

MALEFYT, RD

FIORENTINO, DF

DANG, MN

VIEIRA, P

DEVRIES, J

SPITS, H

MOSMANN, TR

MOORE, KW

机构：

[1] DNAX RES INST MOLEC & CELLULAR BIOL INC, DEPT IMMUNOL, 901 CALIF AVE, PALO ALTO, CA 94304 USA

[2] DNAX RES INST MOLEC & CELLULAR BIOL INC, DEPT HUMAN IMMUNOL, PALO ALTO, CA 94304 USA

来源：

SCIENCE | 1990年 / 250卷 / 4982期

关键词：

D O I：

10.1126/science.2173142

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Cytokine synthesis inhibitory factor (CSIF; interleukin-10), a product of mouse TH2 T cell clones that inhibits synthesis of cytokines by mouse TH1 T cell clones, exhibits extensive sequence similarity to an uncharacterized open reading frame in the Epstein-Barr virus BCRF1. Recombinant BCRF1 protein mimics the activity of interleukin-10, suggesting that BCRF1 may have a role in the interaction of the virus with the host's immune system.

引用

页码：830 / 832

页数：3