EXPRESSION OF INTERLEUKIN-10 ACTIVITY BY EPSTEIN-BARR-VIRUS PROTEIN BCRF1

被引：468
作者：
HSU, DH
MALEFYT, RD
FIORENTINO, DF
DANG, MN
VIEIRA, P
DEVRIES, J
SPITS, H
MOSMANN, TR
MOORE, KW
机构：
[1] DNAX RES INST MOLEC & CELLULAR BIOL INC, DEPT IMMUNOL, 901 CALIF AVE, PALO ALTO, CA 94304 USA
[2] DNAX RES INST MOLEC & CELLULAR BIOL INC, DEPT HUMAN IMMUNOL, PALO ALTO, CA 94304 USA
来源：
SCIENCE | 1990年 / 250卷 / 4982期
关键词：
D O I：
10.1126/science.2173142
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Cytokine synthesis inhibitory factor (CSIF; interleukin-10), a product of mouse TH2 T cell clones that inhibits synthesis of cytokines by mouse TH1 T cell clones, exhibits extensive sequence similarity to an uncharacterized open reading frame in the Epstein-Barr virus BCRF1. Recombinant BCRF1 protein mimics the activity of interleukin-10, suggesting that BCRF1 may have a role in the interaction of the virus with the host's immune system.
引用
收藏
页码：830 / 832
页数：3
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