POTENT ANTIPNEUMOCYSTIS AND ANTITOXOPLASMA ACTIVITIES OF PIRITREXIM, A LIPID-SOLUBLE ANTIFOLATE

被引:99
作者
KOVACS, JA [1 ]
ALLEGRA, CJ [1 ]
SWAN, JC [1 ]
DRAKE, JC [1 ]
PARRILLO, JE [1 ]
CHABNER, BA [1 ]
MASUR, H [1 ]
机构
[1] NCI,CLIN PHARMACOL BRANCH,BETHESDA,MD 20892
关键词
D O I
10.1128/AAC.32.4.430
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
引用
收藏
页码:430 / 433
页数:4
相关论文
共 17 条
[1]   TRIMETREXATE FOR THE TREATMENT OF PNEUMOCYSTIS-CARINII PNEUMONIA IN PATIENTS WITH ACQUIRED-IMMUNODEFICIENCY-SYNDROME [J].
ALLEGRA, CJ ;
CHABNER, BA ;
TUAZON, CU ;
OGATAARAKAKI, D ;
BAIRD, B ;
DRAKE, JC ;
SIMMONS, JT ;
LACK, EE ;
SHELHAMER, JH ;
BALIS, F ;
WALKER, R ;
KOVACS, JA ;
LANE, HC ;
MASUR, H .
NEW ENGLAND JOURNAL OF MEDICINE, 1987, 317 (16) :978-985
[2]   ACTIVITY OF ANTIFOLATES AGAINST PNEUMOCYSTIS-CARINII DIHYDROFOLATE-REDUCTASE AND IDENTIFICATION OF A POTENT NEW AGENT [J].
ALLEGRA, CJ ;
KOVACS, JA ;
DRAKE, JC ;
SWAN, JC ;
CHABNER, BA ;
MASUR, H .
JOURNAL OF EXPERIMENTAL MEDICINE, 1987, 165 (03) :926-931
[3]   POTENT INVITRO AND INVIVO ANTITOXOPLASMA ACTIVITY OF THE LIPID-SOLUBLE ANTIFOLATE TRIMETREXATE [J].
ALLEGRA, CJ ;
KOVACS, JA ;
DRAKE, JC ;
SWAN, JC ;
CHABNER, BA ;
MASUR, H .
JOURNAL OF CLINICAL INVESTIGATION, 1987, 79 (02) :478-482
[4]   INVIVO ACTIVITY OF PIRITREXIN AGAINST TOXOPLASMA-GONDII [J].
ARAUJO, FG ;
GUPTILL, DR ;
REMINGTON, JS .
JOURNAL OF INFECTIOUS DISEASES, 1987, 156 (05) :828-830
[5]  
BERTINO J R, 1964, Methods Med Res, V10, P297
[6]   SIMULTANEOUS ANALYSIS OF FAMILIES OF SIGMOIDAL CURVES - APPLICATION TO BIOASSAY, RADIOLIGAND ASSAY, AND PHYSIOLOGICAL DOSE-RESPONSE CURVES [J].
DELEAN, A ;
MUNSON, PJ ;
RODBARD, D .
AMERICAN JOURNAL OF PHYSIOLOGY, 1978, 235 (02) :E97-E102
[7]   ASSESSMENT OF THERAPY FOR TOXOPLASMA ENCEPHALITIS - THE TE STUDY-GROUP [J].
HAVERKOS, HW .
AMERICAN JOURNAL OF MEDICINE, 1987, 82 (05) :907-914
[8]   POTENT EFFECT OF TRIMETREXATE, A LIPID-SOLUBLE ANTIFOLATE, ON TOXOPLASMA-GONDII [J].
KOVACS, JA ;
ALLEGRA, CJ ;
CHABNER, BA ;
SWAN, JC ;
DRAKE, J ;
LUNDE, M ;
PARRILLO, JE ;
MASUR, H .
JOURNAL OF INFECTIOUS DISEASES, 1987, 155 (05) :1027-1032
[9]   PNEUMOCYSTIS-CARINII PNEUMONIA - A COMPARISON BETWEEN PATIENTS WITH THE ACQUIRED IMMUNODEFICIENCY SYNDROME AND PATIENTS WITH OTHER IMMUNODEFICIENCIES [J].
KOVACS, JA ;
HIEMENZ, JW ;
MACHER, AM ;
STOVER, D ;
MURRAY, HW ;
SHELHAMER, J ;
LANE, HC ;
URMACHER, C ;
HONIG, C ;
LONGO, DL ;
PARKER, MM ;
NATANSON, C ;
PARRILLO, JE ;
FAUCI, AS ;
PIZZO, PA ;
MASUR, H .
ANNALS OF INTERNAL MEDICINE, 1984, 100 (05) :663-671
[10]   DAPSONE-TRIMETHOPRIM FOR PNEUMOCYSTIS-CARINII PNEUMONIA IN THE ACQUIRED-IMMUNODEFICIENCY-SYNDROME [J].
LEOUNG, GS ;
MILLS, J ;
HOPEWELL, PC ;
HUGHES, W ;
WOFSY, C .
ANNALS OF INTERNAL MEDICINE, 1986, 105 (01) :45-48