Emergent cardiovascular risk factors in the very elderly

被引：1
作者：
Moura, Filipe A. [1 ]
Freitas, Wladimir M. [2 ]
Sposito, Andrei C. [2 ]
机构：
[1] Univ Brasilia, Med Sch, Brasilia, DF, Brazil
[2] State Univ Campinas Unicamp, Fac Med Sci, Div Cardiol, Campinas, SP, Brazil
来源：
EXPERT REVIEW OF CARDIOVASCULAR THERAPY | 2012年 / 10卷 / 10期
关键词：
aging; atherogenesis; risk factors; very elderly;
D O I：
10.1586/ERC.12.98
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
An appreciable amount of evidence generated in the recent decades has changed the incidence and mortality of cardiovascular diseases dramatically. This advance has resulted in increased survival and, consequently, in a large new generation of very elderly individuals. In parallel, the aging of the population brought out a puzzle and a challenge for the next millennium. Despite the role of selective survival in attenuating the expression and impact of traditional risk factors, today's elderly still has a gradual increase in unstable plaque formation and, by this way, the incidence of acute cardiovascular events. Recent studies have indicated aging-related emergence of new potential modulators of atherogenesis such as cellular senescence, immunosenescence, the syndrome of frailty, sarcopenia and sirtuins. This review will focus on the most recent and relevant evidence regarding the impact of these new players on atherogenicity in the elderly.
引用
收藏
页码：1221 / 1225
页数：5
相关论文
共 39 条
[21]   Time trends in the prevalence of atherosclerosis: A population-based autopsy study [J].
Roger, VL ;
Weston, SA ;
Killian, JM ;
Pfeifer, EA ;
Belau, PG ;
Kottke, TE ;
Frye, RL ;
Bailey, KR ;
Jacobsen, SJ .
AMERICAN JOURNAL OF MEDICINE, 2001, 110 (04) :267-273
[22]   Population-based study of event-rate, incidence, case fatality, and mortality for all acute vascular events in all arterial territories (Oxford Vascular Study) [J].
Rothwell, PM ;
Coull, AJ ;
Silver, LE ;
Fairhead, JF ;
Giles, MF ;
Lovelock, CE ;
Redgrave, JNE ;
Bull, LM ;
Welch, SJV ;
Cuthbertson, FC ;
Binney, LE ;
Gutnikov, SA ;
Anslow, P ;
Banning, AP ;
Mant, D ;
Mehta, Z .
LANCET, 2005, 366 (9499) :1773-1783
[23]   Telomere length in atherosclerosis and diabetes [J].
Salpea, Klelia D. ;
Humphries, Steve E. .
ATHEROSCLEROSIS, 2010, 209 (01) :35-38
[24]   Decline in skeletal muscle mitochondrial function with aging in humans [J].
Short, KR ;
Bigelow, ML ;
Kahl, J ;
Singh, R ;
Coenen-Schimke, J ;
Raghavakaimal, S ;
Nair, KS .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (15) :5618-5623
[25]   Impact of cellular senescence signature on ageing research [J].
Sikora, Ewa ;
Arendt, Thomas ;
Bennett, Martin ;
Narita, Masashi .
AGEING RESEARCH REVIEWS, 2011, 10 (01) :146-152
[26]   SIRT1 reduces endothelial activation without affecting vascular function in ApoE-/- mice [J].
Stein, Sokrates ;
Schaefer, Nicola ;
Breitenstein, Alexander ;
Besler, Christian ;
Winnik, Stephan ;
Lohmann, Christine ;
Heinrich, Kathrin ;
Brokopp, Chad E. ;
Handschin, Christoph ;
Landmesser, Ulf ;
Tanner, Felix C. ;
Luescher, Thomas F. ;
Matter, Christian M. .
AGING-US, 2010, 2 (06) :353-360
[27]   Global Gene Expression in Skeletal Muscle from Well-Trained Strength and Endurance Athletes [J].
Stepto, Nigel K. ;
Coffey, Vernon G. ;
Carey, Andrew L. ;
Ponnampalam, Anna P. ;
Canny, Benedict J. ;
Powell, David ;
Hawley, John A. .
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, 2009, 41 (03) :546-565
[28]   Molecular genetic studies of gene identification for sarcopenia [J].
Tan, Li-Jun ;
Liu, Shan-Lin ;
Lei, Shu-Feng ;
Papasian, Christopher J. ;
Deng, Hong-Wen .
HUMAN GENETICS, 2012, 131 (01) :1-31
[29]   Characteristics of Framingham offspring participants with long-lived parents [J].
Terry, Dellara F. ;
Evans, Jane C. ;
Pencina, Michael J. ;
Murabito, Joanne M. ;
Vasan, Ramachandran S. ;
Wolf, Philip A. ;
Kelly-Hayes, Margaret ;
Levy, Daniel ;
D'Agostino, Ralph B. ;
Benjamin, Emelia J. .
ARCHIVES OF INTERNAL MEDICINE, 2007, 167 (05) :438-444
[30]   Age-related changes in plaque composition - A study in patients suffering from carotid artery stenosis [J].
van Oostrom, O ;
Velema, E ;
Schoneveld, AH ;
de Vries, JPPM ;
de Bruin, P ;
Seldenrijk, CA ;
de Kleijn, DPV ;
Busser, E ;
Moll, FL ;
Verheijen, JH ;
Virmani, R ;
Pasterkamp, G .
CARDIOVASCULAR PATHOLOGY, 2005, 14 (03) :126-134
1234