Anticholinesterase and Antityrosinase Activities of Ten Piper Species from Malaysia

被引：24

作者：

Salleh, Wan Mohd Nuzul Hakimi Wan ^{[1
]}

Hashim, Nur Athirah ^{[1
]}

Ahmad, Farediah ^{[1
]}

Yen, Khong Heng ^{[2
]}

机构：

[1] Univ Teknol Malaysia, Fac Sci, Dept Chem, Skudai 81310, Malaysia

[2] Univ Teknologi MARA Sarawak, Fac Sci Appl, Sch Chem & Environm Studies, Kota Samarahan 94300, Sarawak, Malaysia

来源：

ADVANCED PHARMACEUTICAL BULLETIN | 2014年 / 4卷

关键词：

Anticholinesterase; Antityrosinase; Piper; Piper erecticaule; Piper porphyrophyllum; Piperaceae;

D O I：

10.5681/apb.2014.078

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Purpose: The aim of this study was to investigate acetylcholinesterase (AChE), butyrylcholinesterase (BChE) and antityrosinase activities of extracts from ten Piper species namely; P. caninum, P. lanatum, P. abbreviatum, P. aborescens, P. porphyrophyllum, P. erecticaule, P. ribesioides, P. miniatum, P. stylosum, and P. majusculum. Methods: Anticholinesterase and antityrosinase activities were evaluated against in vitro Ellman spectroscopy method and mushroom tyrosinase, respectively. Results: The EtOAc extract of P. erecticaule showed the highest AChE and BChE inhibitory with 22.9% and 70.9% inhibition, respectively. In antityrosinase activity, all extracts of P. porphyrophyllum showed the highest inhibitory effects against mushroom tyrosinase, compared to standard, kojic acid. Conclusion: This study showed that P. erecticaule and P. porphyrophyllum have potential AChE/BChE and tyrosinase inhibition activities. The respective extracts can be explored further for the development of novel lead as AChE/BChE and tyrosinase inhibitors in therapeutic management of Alzheimer's disease.

引用

页码：527 / 531

页数：5

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