Anticholinesterase and Antityrosinase Activities of Ten Piper Species from Malaysia

被引:24
作者
Salleh, Wan Mohd Nuzul Hakimi Wan [1 ]
Hashim, Nur Athirah [1 ]
Ahmad, Farediah [1 ]
Yen, Khong Heng [2 ]
机构
[1] Univ Teknol Malaysia, Fac Sci, Dept Chem, Skudai 81310, Malaysia
[2] Univ Teknologi MARA Sarawak, Fac Sci Appl, Sch Chem & Environm Studies, Kota Samarahan 94300, Sarawak, Malaysia
关键词
Anticholinesterase; Antityrosinase; Piper; Piper erecticaule; Piper porphyrophyllum; Piperaceae;
D O I
10.5681/apb.2014.078
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Purpose: The aim of this study was to investigate acetylcholinesterase (AChE), butyrylcholinesterase (BChE) and antityrosinase activities of extracts from ten Piper species namely; P. caninum, P. lanatum, P. abbreviatum, P. aborescens, P. porphyrophyllum, P. erecticaule, P. ribesioides, P. miniatum, P. stylosum, and P. majusculum. Methods: Anticholinesterase and antityrosinase activities were evaluated against in vitro Ellman spectroscopy method and mushroom tyrosinase, respectively. Results: The EtOAc extract of P. erecticaule showed the highest AChE and BChE inhibitory with 22.9% and 70.9% inhibition, respectively. In antityrosinase activity, all extracts of P. porphyrophyllum showed the highest inhibitory effects against mushroom tyrosinase, compared to standard, kojic acid. Conclusion: This study showed that P. erecticaule and P. porphyrophyllum have potential AChE/BChE and tyrosinase inhibition activities. The respective extracts can be explored further for the development of novel lead as AChE/BChE and tyrosinase inhibitors in therapeutic management of Alzheimer's disease.
引用
收藏
页码:527 / 531
页数:5
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