SYNTHESIS OF 7-SUBSTITUTED-4-(3',4',5'-TRISUBSTITUTED-1-PYRAZOLYL)PYRAMIDO-[5,4-C]CINNOLINES AND THEIR ANTIINFLAMMATORY ACTIVITIES

被引：0

作者：

NARGUND, LVG ^{[1
]}

JOSE, R ^{[1
]}

REDDY, YSR ^{[1
]}

机构：

[1] COLL PHARM BELGAUM,DEPT PHARMACEUT CHEM,BELGAUM,KARNATAKA,INDIA

来源：

ARZNEIMITTEL-FORSCHUNG/DRUG RESEARCH | 1994年 / 44-1卷 / 02期

关键词：

ANTIINFLAMMATORIES; PYRAZOLYL-PYRIMIDO[5,4-C]CINNOLINES, PHARMACOLOGY, SYNTHESIS;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Eight title compounds were synthesised from substituted anelines. All compounds were tested for inhibition of bovine serum albumin denaturation. Few selected compounds were studied for their ability to provide protection against carrageenin-induced edema in rat paw and to inhibit denaturation of bovine serum albumin in an attempt to elucidate their cellular mechanism of action. There was no relationship between anti-inflammatory activity of 7-substituted-4-(3',4',5'-trisubstituted-1-pyrazolyl)pyrimido [5,4-c] cinnolines and their bovine serum albumin denaturation effectiveness.

引用

页码：156 / 158

页数：3

共 22 条

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