NEURAL CREST-DERIVED SPINAL AND CRANIAL SENSORY NEURONS ARE EQUALLY SENSITIVE TO NGF BUT DIFFER IN THEIR RESPONSE TO TISSUE-EXTRACTS

被引：30
作者：
DAVIES, AM [1 ]
LINDSAY, RM [1 ]
机构：
[1] NATL INST MED RES, NEUROBIOL LAB, LONDON NW7 1AA, ENGLAND
来源：
DEVELOPMENTAL BRAIN RESEARCH | 1984年 / 14卷 / 01期
关键词：
D O I：
10.1016/0165-3806(84)90015-4
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The response of 2 distinct populations of neural crest-derived sensory neurons to nerve growth factor (NGF) and other neurotrophic activities present in extracts of chick tissues were studied in vitro. Dorsal root ganglia (DRG) and the dorso-medial part of the trigeminal ganglion (DM-TG) from embryonic chicks of 6-11 days of incubations (E6-E11) were grown as either explant or dissociated neuron-enriched cultures. Over the age range studied NGF promoted survival and pronounced neurite outgrowth from both DRG and DM-TG neurons. Whilst extracts of chick eye, liver and spinal cord also elicited a marked response from E8 and older DRG neurons, DM-TG neurons were almost entirely unresponsive to the neurotrophic activity of these extracts.
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页码：121 / 127
页数：7
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