Diabetic cardiomyopathy: signaling defects and therapeutic approaches

被引:50
作者
Dobrin, Joseph S. [1 ]
Lebeche, Djamel [1 ]
机构
[1] Mt Sinai Sch Med, Cardiovasc Res Ctr, Atran Bldg AB5-10,One Gustave L Levy Pl,Box 1030, New York, NY 10029 USA
关键词
adipokines; antihyperglycemic drugs; calcium cycling; diabetic cardiomyopathy; gene therapy; glucotoxicity; insulin resistance; lipotoxicity; mitochondrial dysfunction; obesity; stem cell therapy;
D O I
10.1586/ERC.10.17
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Diabetes mellitus is the world's fastest growing disease with high morbidity and mortality rates, predominantly as a result of heart failure. A significant number of diabetic patients exhibit diabetic cardiomyopathy; that is, left ventricular dysfunction independent of coronary artery disease or hypertension. The pathogenesis of diabetic cardiomyopathy is complex, and is characterized by dysregulated lipid metabolism, insulin resistance, mitochondrial dysfunction and disturbances in adipokine secretion and signaling. These abnormalities lead to impaired calcium homeostasis, ultimately resulting in lusitropic and inotropic defects. This article discusses the impact of these hallmark factors in diabetic cardiomyopathy, and concludes with a survey of available and emerging therapeutic modalities.
引用
收藏
页码:373 / 391
页数:19
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