GROWTH-HORMONE IN THE TREATMENT OF SHORT STATURE IN TURNERS-SYNDROME

被引：0

作者：

MENDOZAMORFIN, F ^{[1
]}

MONTEROGONZALEZ, P ^{[1
]}

CARDENASTIRADO, H ^{[1
]}

BRAVORIOS, LE ^{[1
]}

机构：

[1] INST MEXICANO SEGURO SOCIAL, GEN HOSP, CTR MED NACL LA RAZA, DEPT CLIN ENDOCRINOL PEDIAT, MEXICO CITY 06700, DF, MEXICO

来源：

REVISTA DE INVESTIGACION CLINICA-CLINICAL AND TRANSLATIONAL INVESTIGATION | 1995年 / 47卷 / 05期

关键词：

TURNERS SYNDROME; BIOSYNTHETIC GROWTH HORMONE;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Fifteen patients with Turner's syndrome with ages between 6.8 to 13.2 years were treated with biosynthetic growth hormone due to their low height. Twelve of them had a 45XO cariotype and three were mosaics; none had a Y line. They started with 0.7 IU/kg/week which were increased to 1.0 IU/kg/week if no height gain was observed during three months. The 15 patients have completed one year of treatment, 8 of them for two years. The height velocity increased significantly (p < 0.001) from 0.24 +/- 0.10 cm/month before treatment (mean +/- SD) to 0.48 +/- 0.09 in the first 12 months of treatment (height increased from 119.1 +/- 8.79 to 124.9 +/- 8.70). In the eight cases who have reached 24 months of treatment, the height velocity increased from 0.27 +/- 0.07 cm/month to 0.47 +/- 0.09 and 0.54 +/- 0.10 at 12 and 24 months respectively (p < 0.001 and p < 0.01 versus the pretreatment gain); height increased from 116.8 +/- 7.0 cm to 122.0 +/- 7.45 and 129.0 +/- 7.18. We found no adverse effects in the patients. It is concluded that the biosynthetic growth hormone treatment in Turner's syndrome can improve low height.

引用

页码：371 / 376

页数：6