ANTIBODY TO HISTO-BLOOD GROUP-A ANTIGEN NEUTRALIZES HIV PRODUCED BY LYMPHOCYTES FROM BLOOD GROUP-A DONORS BUT NOT FROM BLOOD GROUP-B OR GROUP-O DONORS

被引：37

作者：

ARENDRUP, M

HANSEN, JES

CLAUSEN, H

NIELSEN, C

MATHIESEN, LR

NIELSEN, JO

机构：

[1] ROYAL DENT COLL,DEPT ORAL DIAGNOST,DK-2100 COPENHAGEN,DENMARK

[2] STATE SERUM INST,DEPT VIROL,COPENHAGEN,DENMARK

来源：

AIDS | 1991年 / 5卷 / 04期

关键词：

HIV; NEUTRALIZATION; MONOCLONAL ANTIBODY; CARBOHYDRATE EPITOPES; GLYCOSYLATION; ISOLATE-SPECIFIC; HOST-CELL-SPECIFIC; BLOOD GROUP-A ANTIGEN;

D O I：

10.1097/00002030-199104000-00014

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Three virus isolates HTLV-III(B)/lyA, HTLV-III(B)/lyB and HTLV-III(B)/lyO, obtained by passaging and propagating the HTLV-III(B)/H9 isolate in three separate cultures of mixed peripheral blood mononuclear cells (PBMC) from donors of blood type A, B or O, respectively, were tested for susceptibility for virus neutralization by the monoclonal antibody (MAb) AH16 directed against the blood group A epitope. MAb AH16 was previously shown to inhibit cell-free virus infection using HTLV-III(B) propagated in H9 cells. AH16 showed a concentration-dependent inhibition of the HTLV-III(B)/lyA isolate but did not inhibit the HTLV-III(B)/lyB or the HTLV-III(B)/lyO isolate. Specificity of the MAb-mediated inhibition was shown using A-antigen (tetrasaccharide). Thus, HIV infection of PBMC from donors with blood type A appears to induce expression of host-cell-encoded carbohydrate blood group A epitope on HIV which can be a target for MAb-mediated virus neutralization.

引用

页码：441 / 444

页数：4

共 18 条

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