Core-Shell gamma-Fe2O3/SiO2/PCA/Ag-NPs Hybrid Nanomaterials as a New Candidate for Future Cancer Therapy

被引：2

作者：

Soleyman, R. ^{[1
]}

Pourjavadi, A. ^{[2
]}

Masoud, N. ^{[2
]}

Varamesh, A. ^{[1
]}

机构：

[1] Res Inst Petr Ind, Polymer Sci & Technol Div, Tehran, Iran

[2] Sharif Univ Technol, Dept Chem, Polymer Res Lab, Tehran, Iran

来源：

INTERNATIONAL JOURNAL OF NANOSCIENCE | 2014年 / 13卷 / 01期

关键词：

Hybrid nanomaterials; gamma-Fe2O3; poly citric acid; silver nanoparticles;

D O I：

10.1142/S0219581X14500082

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

In the current study, gamma-Fe2O3/SiO2/PCA/Ag-NPs hybrid nanomaterials were successfully synthesized and characterized. At first, prepared gamma-Fe2O3 core nanoparticles were modified by SiO2 layer. Then they were covered by poly citric acid (PCA) via melting esterification method as well. PCA shell acts as an effective linker, and provides vacancies for conveying drugs. Moreover, this shell as an effective capping agent directs synthesis of silver nanoparticles (AgNPs) via in situ photo-reduction of silver ions by sunlight- UV irradiation. This system has several benefits as a suitable cancer therapy nanomaterial. Magnetic nanoparticles (MNPs) can guide Ag-NPs and drugs to cancer cells and then Ag-NPs can affect those cells via Ag-NPs antiangiogenesis effect. Size and structure of the prepared magnetic hybrid nanomaterials were characterized using FTIR and UV-Vis spectra, AFM and TEM pictures and XRD data.

引用

页数：7

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