THE CORRELATION BETWEEN METABOLIC DISORDERS AND TPOAB/TGAB: A CROSS-SECTIONAL POPULATION-BASED STUDY

被引：25

作者：

Wu, Ying ^{[1
,2
]}

Shi, Xiaoguang ^{[1
,2
]}

Tang, Xulei ^{[3
]}

Li, Yongze ^{[1
,2
]}

Tong, Nanwei ^{[4
]}

Wang, Guixia ^{[5
]}

Zhang, Jin-an ^{[6
,7
]}

Wang, Youmin ^{[8
]}

Ba, Jianming ^{[9
]}

Chen, Bing ^{[10
]}

Du, Jianling ^{[11
]}

He, Lanjie ^{[12
]}

Lai, Xiaoyang ^{[13
]}

Li, Yanbo ^{[14
]}

Chi, Haiyi ^{[15
]}

Liao, Eryuan ^{[16
]}

Liu, Chao ^{[17
]}

Liu, Libin ^{[18
]}

Qin, Guijun ^{[19
]}

Qin, Yingfen ^{[20
]}

Quan, Huibiao ^{[21
]}

Shi, Bingyin ^{[22
]}

Sun, Hui ^{[23
]}

Xue, Yuanming ^{[24
]}

Yan, Li ^{[25
]}

Yang, Jing ^{[26
]}

Yang, Lihui ^{[27
]}

Yao, Yongli ^{[28
]}

Ye, Zhen ^{[29
]}

Zhang, Qiao ^{[30
]}

Zhang, Lihui ^{[31
]}

Zhu, Jun ^{[32
]}

Zhu, Mei ^{[33
]}

Teng, Weiping ^{[1
,2
]}

Shan, Zhongyan ^{[1
,2
]}

机构：

[1] China Med Univ, Dept Endocrinol & Metab, Hosp 1, 155 Nanjing Bei St, Shenyang 110001, Liaoning, Peoples R China

[2] China Med Univ, Inst Endocrinol, Hosp 1, 155 Nanjing Bei St, Shenyang 110001, Liaoning, Peoples R China

[3] Lanzhou Univ, Dept Endocrinol, Hosp 1, Lanzhou, Gansu, Peoples R China

[4] Sichuan Univ, West China Hosp, Dept Endocrinol & Metab, State Key Lab Biotherapy, Chengdu, Sichuan, Peoples R China

[5] First Hosp Jilin Univ, Dept Endocrinol & Metab, Changchun, Jilin, Peoples R China

[6] Shanghai Univ Med, Dept Endocrinol, Shanghai, Peoples R China

[7] Hlth Sci Affiliated Zhoupti Hosp, Shanghai, Peoples R China

[8] An Hui Med Univ, Dept Endocrinol, Hosp 1, Hefei, Anhui, Peoples R China

[9] Chinese Peoples Liberat Army Gen Hosp, Dept Endocrinol, Beijing, Peoples R China

[10] Third Mil Med Univ, Southwest Hosp, Dept Endocrinol, Chongqing, Peoples R China

[11] Dalian Med Univ, Dept Endocrinol, Affiliated Hosp 1, Dalian, Liaoning, Peoples R China

[12] Ningxia Med Univ, Dept Endocrinol, Cardiovasc & Cerebrovasc Dis Hosp, Yinchuan, Ningxia, Peoples R China

[13] Nanchang Univ, Dept Endocrinol & Metab, Affiliated Hosp 2, Nanchang, Jiangxi, Peoples R China

[14] Harbin Med Univ, Dept Endocrinol, Affiliated Hosp 1, Harbin, Heilongjiang, Peoples R China

[15] Hohhot First Hosp, Dept Endocrinol, Hohhot, Inner Mongolia, Peoples R China

[16] Cent South Univ, Xiangya Hosp 2, Dept Endocrinol & Metab, Changsha, Hunan, Peoples R China

[17] Nanjing Univ Chinese Med, Affiliated Hosp Integrated Tradit Chinese & Weste, Res Ctr Endocrine & Metab Dis, Nanjing, Jiangsu, Peoples R China

[18] Fujian Med Univ, Fujian Inst Endocrinol, Dept Endocrinol & Metab, Union Hosp, Fuzhou, Fujian, Peoples R China

[19] Zhengzhou Univ, Affiliated Hosp 1, Dept Internal Med, Div Endocrinol, Zhengzhou, Henan, Peoples R China

[20] Guangxi Med Univ, Dept Endocrine, Affiliated Hosp 1, Nanning, Guangxi, Peoples R China

[21] Hainan Gen Hosp, Dept Endocrinol, Haikou, Hainan, Peoples R China

[22] Xi An Jiao Tong Univ, Dept Endocrinol, Affiliated Hosp 1, Xian, Shanxi, Peoples R China

[23] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Endocrinol, Wuhan, Hubei, Peoples R China

[24] First Peoples Hosp Yunnan Prov, Dept Endocrinol, Kunming, Yunnan, Peoples R China

[25] Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Endocrinol & Metab, Guangzhou, Guangdong, Peoples R China

[26] Shanxi Med Univ, Dept Endocrinol, Hosp 1, Taiyuan, Shanxi, Peoples R China

[27] Peoples Hosp Tibet Autonomous Reg, Dept Endocrinol & Metab, Lhasa, Tibet, Peoples R China

[28] Qinghai Prov Peoples Hosp, Dept Endocrinol, Xining, Qinghai, Peoples R China

[29] Zhejiang Prov Ctr Dis Control & Prevent, Hangzhou, Zhejiang, Peoples R China

[30] Guiyang Med Univ, Dept Endocrinol & Metab, Affiliated Hosp, Guiyang, Guizhou, Peoples R China

[31] Hebei Med Univ, Dept Endocrinol, Hosp 2, Shijiazhuang, Hebei, Peoples R China

[32] Xinjiang Med Univ, Dept Endocrinol, Affiliated Hosp 1, Urumqi, Xinjiang, Peoples R China

[33] Tianjin Med Univ, Dept Endocrinol & Metab, Gen Hosp, Tianjin, Peoples R China

来源：

ENDOCRINE PRACTICE | 2020年 / 26卷 / 08期

关键词：

VITAMIN-D; AUTOIMMUNE; INFLAMMASOME; ACTIVATION; DISEASES; IMMUNOMETABOLISM; OBESITY; HEALTH;

D O I：

10.4158/EP-2020-0008

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective: Studies have shown that metabolic abnormalities influence the immune system. Because the prevalence of metabolic and autoimmune thyroid diseases has increased synchronously, the correlation between them was worth exploring. The study objective was to investigate the relationship between metabolic disorders and thyroid auto-antibodies in euthyroid subjects. Methods: Data were obtained from the Thyroid Diseases and Diabetes Mellitus project survey of 55,891 subjects from 31 provinces in China. The body mass index (BMI), waist circumference (WC), blood pressure, thyroid peroxidase antibodies (TPOAbs), thyroglobulin antibodies (TgAbs), thyroid-stimulating hormone (TSH), urinary iodine concentration, blood glucose, lipid profile, and uric acid levels were evaluated. Free thyroxine and free triiodothyronine levels were measured in patients with abnormal serum TSH levels. Results: In males, the BMI, WC, systolic blood pressure (SBP), diastolic blood pressure (DBP), and 2-hour post-glucose oral glucose tolerance test results of the TPOAb-/TgAb-positive group were significantly higher than those of the TPOAb-/TgAb-negative group. In females, the BMI, WC, SBP, DBP, total cholesterol, and low-density-lipoprotein cholesterol (LDL-C) in the TPOAb-/TgAb-positive group were significantly increased compared to the TPOAb-/TgAb-negative group. Multivariate analysis showed that in males, the odds ratio (OR) of positive TgAbs in the abdominal obesity group was 1.175 (95% confidence interval [CI], 1.016 to 1.359; P =.03), and the OR of positive TPOAbs in the hyperuricemia group was 1.195 (95% CI, 1.041 to 1.372; P =.011). In females, the OR of positive TgAbs was 1.19 (95% CI, 1.068 to 1.326; P =.002) in the high LDL-C group. Conclusion: Obesity, high LDL-C, and hyperuricemia were positively correlated with the prevalence of positive thyroid autoantibodies in euthyroid subjects in a gender-dependent manner. This cross-sectional survey showed that metabolic disorders are associated with increased positive thyroid autoantibody levels in euthyroid subjects in a gender-dependent manner.

引用

页码：869 / 882

页数：14

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