LONG-TERM PERSISTENCE OF STERILE IMMUNITY IN A VOLUNTEER IMMUNIZED WITH X-IRRADIATED PLASMODIUM-FALCIPARUM SPOROZOITES

被引:69
作者
EDELMAN, R
HOFFMAN, SL
DAVIS, JR
BEIER, M
SZTEIN, MB
LOSONSKY, G
HERRINGTON, DA
EDDY, HA
HOLLINGDALE, MR
GORDON, DM
CLYDE, DF
机构
[1] UNIV MARYLAND,SCH MED,DEPT MED,DIV GEOG MED,BALTIMORE,MD 21201
[2] UNIV MARYLAND,SCH MED,DEPT PEDIAT,DIV INFECT DIS & TROP PEDIAT,BALTIMORE,MD 21201
[3] UNIV MARYLAND,SCH MED,DEPT RADIAT ONCOL,BALTIMORE,MD 21201
[4] USN,MED RES INST,DEPT DEF,MALARIA VACCINE PROGRAM,BETHESDA,MD 20814
[5] WALTER REED ARMY INST RES,DEPT DEF,MALARIA VACCINE PROGRAM,WASHINGTON,DC 20307
[6] BIOMED RES INST,ROCKVILLE,MD
关键词
D O I
10.1093/infdis/168.4.1066
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Three volunteers were immunized by repeated exposure to the bites of Plasmodium falciparum-infected, X-irradiated mosquitoes to characterize immunologic responses and duration of protective immunity. A primary series of immunizations had been shown previously to induce sterile immunity in these volunteers against sporozoite-induced P. falciparum malaria. In the current study, antibodies to sporozoites circulated at high levels for at least 9-12 months after the volunteers were administered booster bites from X-irradiated infective mosquitoes. One volunteer challenged a second time with P. falciparum 9 months after his last immunization was again shown to be protected, whereas all 5 control subjects developed patent infections. These results set a new standard for persistence of sterile immunity against experimental P. falciparum infection.
引用
收藏
页码:1066 / 1070
页数:5
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