RELEASE OF ENDOTHELIN FROM CULTURED BOVINE ENDOTHELIAL-CELLS

被引：28

作者：

PRASAD, MR ^{[1
]}

JONES, RM ^{[1
]}

KREUTZER, DL ^{[1
]}

机构：

[1] UNIV CONNECTICUT, CTR HLTH, DEPT PATHOL, FARMINGTON, CT 06030 USA

来源：

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY | 1991年 / 23卷 / 06期

关键词：

FREE RADICALS; ENDOTHELIN; ENDOTHELIUM;

D O I：

10.1016/0022-2828(91)90974-Q

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Recently discovered endothelin is a powerful vasoconstrictor of vascular smooth muscle in vitro, which also profoundly affects the mechanical function of the heart [1, 2]. An increased level of plasma endothelin in patients with acute myocardial infarction suggests the enhanced release of endothelin from vascular endothelium under pathophysiological conditions of the heart [3]. The reperfusion of ischemic myocardium is associated with the activation of polymorphonuclear leukocytes (PMN) generating oxygen-derived free radicals (OFR), as well as, enhanced responsiveness of myocardial α1-adrenergic receptors [4,5]. Both OFR and catecholamines are implicated in the modulation of release of endothelium-derived peptides [6]. © 1991.

引用

页码：655 / 658

页数：4

共 13 条

[1] INCREASED ALPHA-ADRENERGIC RECEPTORS IN ISCHEMIC CAT MYOCARDIUM - A POTENTIAL MEDIATOR OF ELECTRO-PHYSIOLOGICAL DERANGEMENTS [J].

CORR, PB ;

SHAYMAN, JA ;

KRAMER, JB .

JOURNAL OF CLINICAL INVESTIGATION, 1981, 67 (04) :1232-1236

[2]

ENGLER RL, 1983, AM J PATHOL, V111, P98

[3] THE DEOXYRIBOSE METHOD - A SIMPLE TEST-TUBE ASSAY FOR DETERMINATION OF RATE CONSTANTS FOR REACTIONS OF HYDROXYL RADICALS [J].

HALLIWELL, B ;

GUTTERIDGE, JMC ;

ARUOMA, OI .

ANALYTICAL BIOCHEMISTRY, 1987, 165 (01) :215-219

[4] EFFECTS OF ENDOTHELIN ON CORONARY FLOW, MECHANICAL PERFORMANCE, OXYGEN-UPTAKE, AND FORMATION OF PURINES AND ON OUTFLOW OF PROSTACYCLIN IN THE ISOLATED RABBIT HEART [J].

KARWATOWSKAPROKOPCZUK, E ;

WENNMALM, A .

CIRCULATION RESEARCH, 1990, 66 (01) :46-54

[5] PRODUCTION OF ENDOTHELIN BY CULTURED PORCINE ENDOTHELIAL-CELLS - MODULATION BY ADRENALINE [J].

KOHNO, M ;

MURAKAWA, K ;

YOKOKAWA, K ;

YASUNARI, K ;

HORIO, T ;

KURIHARA, N ;

TAKEDA, T .

JOURNAL OF HYPERTENSION, 1989, 7 :S130-S131

[6] ROLE OF IRON ON MEMBRANE PHOSPHOLIPID BREAKDOWN IN ISCHEMIC-REPERFUSED RAT-HEART [J].

LIU, XK ;

PRASAD, MR ;

ENGELMAN, RM ;

JONES, RM ;

DAS, DK .

AMERICAN JOURNAL OF PHYSIOLOGY, 1990, 259 (04) :H1101-H1107

[7] LEUKOCYTES AND ISCHEMIA-INDUCED MYOCARDIAL INJURY [J].

LUCCHESI, BR ;

MULLANE, KM .

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, 1986, 26 :201-224

[8]

NEWBY AC, 1990, ANNU REV PHYSIOL, V52, P661

[9] EFFECTS OF D-VALINE ON PULMONARY-ARTERY ENDOTHELIAL-CELL MORPHOLOGY AND FUNCTION IN CELL-CULTURE [J].

PICCIANO, PT ;

JOHNSON, B ;

WALENGA, RW ;

DONOVAN, M ;

BORMAN, BJ ;

DOUGLAS, WHJ ;

KREUTZER, DL .

EXPERIMENTAL CELL RESEARCH, 1984, 151 (01) :134-147

[10] EFFECT OF OXYGEN-DERIVED FREE-RADICALS AND OXIDANTS ON THE DEGRADATION INVITRO OF MEMBRANE PHOSPHOLIPIDS [J].

PRASAD, MR ;

DAS, DK .

FREE RADICAL RESEARCH COMMUNICATIONS, 1989, 7 (3-6) :381-388

← 1 2 →