Practical Guidelines: Lung Transplantation in Patients with Cystic Fibrosis

被引:60
作者
Hirche, T. O. [1 ]
Knoop, C. [2 ]
Hebestreit, H. [3 ]
Shimmin, D. [4 ]
Sole, A. [5 ]
Elborn, J. S. [6 ,7 ]
Ellemunter, H. [8 ]
Aurora, P. [9 ]
Hogardt, M. [10 ]
Wagner, T. O. F. [11 ,12 ]
机构
[1] German Clin Diagnost DKD, Dept Pulm Med, Wiesbaden, Germany
[2] Erasme Univ Hosp, Dept Chest Med, Brussels, Belgium
[3] Univ Hosp Wuerzburg, Dept Pediat, Wurzburg, Germany
[4] Belfast City Hosp, Reg Adult CF Ctr, Belfast, Antrim, North Ireland
[5] Hosp Univ La Fe, Lung Transplant Unit, Valencia, Spain
[6] Queens Univ Belfast, Ctr Infect & Immun, Belfast, Antrim, North Ireland
[7] BHSCT, Adult CF Ctr, Belfast, Antrim, North Ireland
[8] Med Univ Innsbruck, Cyst Fibrosis Ctr, Dept Pediat, Innsbruck, Austria
[9] Great Ormond St Hosp Sick Children, Paediat Resp Med & Lung Transplantat, London, England
[10] Goethe Univ Hosp Frankfurt, Inst Med Microbiol & Infect Control, Frankfurt, Germany
[11] Goethe Univ Hosp Frankfurt, Dept Pneumol, Frankfurt, Germany
[12] Frankfurt Univ Hosp, Dept Pneumol, D-60590 Frankfurt, Germany
关键词
D O I
10.1155/2014/621342
中图分类号
R56 [呼吸系及胸部疾病];
学科分类号
摘要
There are no European recommendations on issues specifically related to lung transplantation (LTX) in cystic fibrosis (CF). The main goal of this paper is to provide CF care team members with clinically relevant CF-specific information on all aspects of LTX, highlighting areas of consensus and controversy throughout Europe. Bilateral lung transplantation has been shown to be an important therapeutic option for end-stage CF pulmonary disease. Transplant function and patient survival after transplantation are better than in most other indications for this procedure. Attention though has to be paid to pretransplant morbidity, time for referral, evaluation, indication, and contraindication in children and in adults. This review makes extensive use of specific evidence in the field of lung transplantation in CF patients and addresses all issues of practical importance. The requirements of pre-, peri-, and postoperative management are discussed in detail including bridging to transplant and postoperative complications, immune suppression, chronic allograft dysfunction, infection, and malignancies being the most important. Among the contributors to this guiding information are 19 members of the ECORN-CF project and other experts. The document is endorsed by the European Cystic Fibrosis Society and sponsored by the Christiane Herzog Foundation.
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页数:22
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