The Interplay between Autophagy and Aging

被引：25
|
作者：
Pyo, Jong-Ok [1 ]
Yoo, Seung-Min [1 ]
Jung, Yong-Keun [1 ]
机构：
[1] Seoul Natl Univ, Sch Biol Sci, Bio MAX Inst, Seoul, South Korea
来源：
DIABETES & METABOLISM JOURNAL | 2013年 / 37卷 / 05期
关键词：
Aging; Autophagy; Caloric restriction; Mitochondria; Stress;
D O I：
10.4093/dmj.2013.37.5.333
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Numerous studies have established a link between autophagy and aging; however, the relationship has not been clearly defined. Aging is a very complex process caused by the accumulation of various factors due to the gradual failure of cellular maintenance. Recent studies have shown that autophagy reduces the stress responses induced by starvation, reactive oxygen species, and the accumulation of intracellular proteins and organelles through cytoprotection, clearance of damaged mitochondria, and lysosomal degradation. Here, we summarize our current understanding of the relationship between autophagy and the aging process.
引用
收藏
页码：333 / 339
页数：7
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