SEQUENCED REACTIONS WITH SAMARIUM(II) IODIDE - TANDEM INTRAMOLECULAR NUCLEOPHILIC ACYL SUBSTITUTION/INTRAMOLECULAR BARBIER CYCLIZATIONS

被引：97
作者：
MOLANDER, GA
HARRIS, CR
机构：
[1] Department of Chemistry and Biochemistry, University of Colorado, Boulder, Colorado
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 1995年 / 117卷 / 13期
关键词：
D O I：
10.1021/ja00118a007
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Samarium(II) iodide has been employed to promote a tandem intramolecular nucleophilic acyl substitution/intramolecular Barbier cyclization sequence, generating bicyclic and tricyclic ring systems in excellent yield and high diastereoselectivity. Additionally, a highly versatile ring expansion-cyclization sequence allows entry into several different naturally occurring tricyclic ring systems containing seven- and eight-membered rings.
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页码：3705 / 3716
页数：12
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