ANGIOTENSIN-II RAPIDLY MODULATES THE RENAL PERIPHERAL BENZODIAZEPINE RECEPTOR

被引：12

作者：

HOLMES, PV ^{[1
]}

DRUGAN, RC ^{[1
]}

机构：

[1] BROWN UNIV,DEPT PSYCHOL,SCHRIER RES LAB,BOX 1853,PROVIDENCE,RI 02912

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY-MOLECULAR PHARMACOLOGY SECTION | 1992年 / 226卷 / 02期

关键词：

KIDNEY (RAT); BENZODIAZEPINE RECEPTORS (PERIPHERAL); ANGIOTENSIN-II;

D O I：

10.1016/0922-4106(92)90184-W

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effects of acute exposure to angiotensin II (AII) on the renal peripheral benzodiazepine receptor were studied in rats. As little as 37.5-mu-g of AII injected s.c. over an 80 min period caused immediate reductions in [H-3]Ro5-4864 binding. Scatchard analysis revealed that the reduction in [H-3]Ro5-4864 binding induced by AII was due to a drop in receptor density or B(max). The influence of AII on the peripheral benzodiazepine receptor is similar to that of stress.

引用

页码：189 / 190

页数：2

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