OXIDIZED LOW-DENSITY LIPOPROTEINS EXERT ARRHYTHMOGENIC EFFECTS IN RABBIT PURKINJE-FIBERS

被引：6

作者：

ADAMANTIDIS, MM ^{[1
]}

MOREAUGUEDON, L ^{[1
]}

MARTINNIZARD, F ^{[1
]}

SQALLIHOUSSAINI, H ^{[1
]}

DURIEZ, P ^{[1
]}

FRUCHART, JC ^{[1
]}

DUPUIS, B ^{[1
]}

机构：

[1] INST PASTEUR,SERLIA,INSERM,4325,F-59019 LILLE,FRANCE

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 182卷 / 02期

关键词：

D O I：

10.1016/0006-291X(92)91767-K

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The electrophysiological effects of oxidized low density lipoproteins (ox-LDLs) have been studied in rabbit Purkinje fibers using standard microelectrode techniques, in comparison with native LDLs (n-LDLs) and lysophosphatidylcholine (LPC). At the concentration of 100 μg protein/ml, ox-LDL but never n-LDL induced the abrupt occurrence of abnormal electrical activities during the basic stimulation of 1 Hz ( 6 13 fibers) and the development of either early afterdepolarizations ( 6 13 fibers) or abnormal automaticity ( 4 13 fibers) at low frequencies (0.1 and 0.03 Hz). Short trains of rapid stimulation (2, 3, 4 and 5 Hz) did not trigger delayed afterdepolarizations. However, early afterhyperpolarizations were commonly seen after each action potential. 30 μM LPC caused quite similar electrophysiological derangements. The results suggest that ox-LDLs may exert arrhythmogenic effects partly explained by their LPC content. © 1992.

引用

页码：548 / 554

页数：7

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