TUMOR-NECROSIS-FACTOR-ALPHA IN AUTOIMMUNITY - PRETTY GIRL OR OLD WITCH

被引:129
作者
JACOB, CO
机构
[1] Dept of Inflammation Biology and Immunology, Syntex Research, Palo Alto
来源
IMMUNOLOGY TODAY | 1992年 / 13卷 / 04期
关键词
D O I
10.1016/0167-5699(92)90107-I
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The role of TNF-alpha in the pathogenesis of autoimmune disorders is poorly understood. Evidence in favor of a pathogenic role bas come mainly from in vitro experiments, while in vivo studies in animal models have suggested a protective role. In this article, Chaim Jacob attempts to reconcile these apparently contradictory studies.
引用
收藏
页码:122 / 125
页数:4
相关论文
共 41 条
[1]   ASSOCIATION BETWEEN HLA-DR2 AND PRODUCTION OF TUMOR NECROSIS FACTOR-ALPHA AND INTERLEUKIN-1 BY MONONUCLEAR-CELLS ACTIVATED BY LIPOPOLYSACCHARIDE [J].
BENDTZEN, K ;
MORLING, N ;
FOMSGAARD, A ;
SVENSON, M ;
JAKOBSEN, B ;
ODUM, N ;
SVEJGAARD, A .
SCANDINAVIAN JOURNAL OF IMMUNOLOGY, 1988, 28 (05) :599-606
[2]   CYTOTOXICITY OF HUMAN PI-7 INTERLEUKIN-1 FOR PANCREATIC-ISLETS OF LANGERHANS [J].
BENDTZEN, K ;
MANDRUPPOULSEN, T ;
NERUP, J ;
NIELSEN, JH ;
DINARELLO, CA ;
SVENSON, M .
SCIENCE, 1986, 232 (4757) :1545-1547
[3]   IMMUNE HORMONES (CYTOKINES) - PATHOGENIC ROLE IN AUTOIMMUNE RHEUMATIC AND ENDOCRINE DISEASES [J].
BENDTZEN, K .
AUTOIMMUNITY, 1989, 2 (02) :177-189
[4]   CONTROL OF CACHECTIN (TUMOR-NECROSIS-FACTOR) SYNTHESIS - MECHANISMS OF ENDOTOXIN RESISTANCE [J].
BEUTLER, B ;
KROCHIN, N ;
MILSARK, IW ;
LUEDKE, C ;
CERAMI, A .
SCIENCE, 1986, 232 (4753) :977-980
[5]  
BEUTLER B, 1991, TUMOR NECROSIS FACTO, P561
[6]  
BOSWELL JM, 1988, J IMMUNOL, V141, P3050
[7]  
BRENNAN DC, 1989, J IMMUNOL, V143, P3470
[8]   DOES MALARIA SELECT FOR PREDISPOSITION TO AUTOIMMUNE-DISEASE [J].
BUTCHER, GA .
JOURNAL OF THE ROYAL SOCIETY OF MEDICINE, 1991, 84 (08) :451-453
[9]   SLE AND MALARIA - ANOTHER LOOK AT AN OLD IDEA [J].
BUTCHER, GA ;
CLARK, IA .
PARASITOLOGY TODAY, 1990, 6 (08) :259-261
[10]   INTERCELLULAR-ADHESION MOLECULE-1 IS INDUCED ON ISOLATED ENDOCRINE ISLET CELLS BY CYTOKINES BUT NOT BY REOVIRUS INFECTION [J].
CAMPBELL, IL ;
CUTRI, A ;
WILKINSON, D ;
BOYD, AW ;
HARRISON, LC .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (11) :4282-4286