INTERSPECIES DIFFERENCES IN EXPRESSION OF CYTOKERATIN POLYPEPTIDES WITHIN THYMIC EPITHELIUM - A COMPARATIVE IMMUNOHISTOCHEMICAL STUDY

被引：19

作者：

COLIC, M

DRAGOJEVICSIMIC, V

GASIC, S

DUJIC, A

机构：

[1] Institute for Experimental Medicine, Military Medical Academy

来源：

DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY | 1990年 / 14卷 / 03期

关键词：

cytokeratins; immunohistochemistry; mammals; Thymic epithelium;

D O I：

10.1016/0145-305X(90)90025-A

中图分类号：

S9 [水产、渔业];

学科分类号：

0908 ;

摘要：

Cytokeratin (CK) polypeptide expression within the thymic epithelium of several mammalian species (mouse, rat, calf, pig, rabbit, and human) has been analyzed by the streptavidin-biotin immunoperoxidase method. Comparative analysis by a large panel of 17 monoclonal antibodies (mAbs) specific for individual CK polypeptides, pairs, or groups showed considerable heterogeneity of thymic epithelial cells (TEC) in each species. In addition, extreme interspecies difference in CK contents was observed. Four main phenotypic zones: the subcapsule/perivascular area, cortex, medulla, and Hassall's corpuscles (HC) were clearly identified, each characterized by different CK expression. Medullary TEC were more heterogenous and shared common CK polypeptides either with subcapsular/perivascular TEC, cortical TEC, or HC, in most species. © 1990.

引用

页码：347 / 354

页数：8

共 23 条

[1]

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[2]

COLIC M, 1988, THYMUS, V12, P123

[3]

COOPER D, 1985, LAB INVEST, V52, P243

[4]

GELFAND EW, 1980, BIOL BASIS IMMUNODEF, P39