Targeting the EGF Receptor for Ovarian Cancer Therapy

被引：53
作者：
Zeineldin, Reema [1 ]
Muller, Carolyn Y. [2 ]
Stack, M. Sharon [3 ]
Hudson, Laurie G. [1 ]
机构：
[1] Univ New Mexico, Coll Pharm, Dept Pharmaceut Sci, Albuquerque, NM 87131 USA
[2] Univ New Mexico, Sch Med, Dept Obstet & Gynecol, Albuquerque, NM 87131 USA
[3] Univ Missouri, Sch Med, Dept Pathol & Anat Sci, Columbia, MO 65212 USA
来源：
JOURNAL OF ONCOLOGY | 2010年 / 2010卷
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1155/2010/414676
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Ovarian carcinoma is the leading cause of death from gynecologic malignancy in the US. Factors such as the molecular heterogeneity of ovarian tumors and frequent diagnosis at advanced stages hamper effective disease treatment. There is growing emphasis on the identification and development of targeted therapies to disrupt molecular pathways in cancer. The epidermal growth factor (EGF) receptor is one such protein target with potential utility in the management of ovarian cancer. This paper will discuss contributions of EGF receptor activation to ovarian cancer pathogenesis and the status of EGF receptor inhibitors and EGF receptor targeted therapies in ovarian cancer treatment.
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页数：11
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