Facile synthesis of 3,4-dihydropyrimidin-2(1H)-ones and -thiones and indeno[1,2-d]pyrimidines catalyzed by p-dodecylbenzenesulfonic acid

被引：37

作者：

Aswin, Krishnamoorthy ^{[1
]}

Mansoor, Syed Sheik ^{[1
]}

Logaiya, Kuppan ^{[1
]}

Sudhan, Prasanna Nithiya ^{[1
]}

Ahmed, Rahim Nasir ^{[1
]}

机构：

[1] C Abdul Hakeem Coll, Dept Chem Res, Bioact Organ Mol Synth Unit, Melvisharam 632509, Tamil Nadu, India

来源：

JOURNAL OF TAIBAH UNIVERSITY FOR SCIENCE | 2014年 / 8卷 / 03期

关键词：

Biginelli reaction; p-Dodecylbenzenesulfonic acid; Dihydropyrimidinone; Indeno[1,2-d]pyrimidine; 2H-Indene-1,3-dione; One-pot synthesis;

D O I：

10.1016/j.jtusci.2014.03.005

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A facile method for synthesizing 3,4-dihydropyrimidin-2(1H)-ones and -thiones in the Biginelli reaction by condensation reaction of aldehydes, beta-ketoesters and urea or thiourea with p-dodecylbenzenesulfonic acid as a recyclable catalyst under solvent-free conditions at 80 degrees C is described. A series of indeno[1,2-cflpyrimidines was also synthesized under the same conditions by a Biginellilike reaction of 2H-indene-1,3-dione with urea or thiourea and an aromatic aldehyde. All the products in both reactions were obtained in good to excellent yield by this simple, efficient procedure. The structures of all the synthesized compounds were established from advanced spectroscopic data. (C) 2014 Taibah University. Production and hosting by Elsevier B.V. All rights reserved.

引用

页码：236 / 247

页数：12

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