FAST SODIUM ACTION-POTENTIALS ARE GENERATED IN THE DISTAL APICAL DENDRITES OF RAT HIPPOCAMPAL CA1 PYRAMIDAL CELLS

被引：24
|
作者：
COLLING, SB [1 ]
WHEAL, HV [1 ]
机构：
[1] UNIV SOUTHAMPTON,DEPT PHYSIOL & PHARMACOL,SOUTHAMPTON SO9 3TU,HANTS,ENGLAND
来源：
NEUROSCIENCE LETTERS | 1994年 / 172卷 / 1-2期
基金：
英国惠康基金;
关键词：
HIPPOCAMPUS; QX-314; LOCAL ANESTHETIC; DENDRITIC ACTION POTENTIAL; SODIUM CHANNEL; EXCITATORY POSTSYNAPTIC POTENTIAL; APICAL DENDRITE;
D O I：
10.1016/0304-3940(94)90665-3
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Intracellular recording techniques were used to monitor the evoked responses in hippocampal CA1 pyramidal cells following focal stimulation of the proximally and distally located apical dendritic synapses. The local anaesthetic, QX-314, when injected into individual cells, caused a complete time-dependent blockade of the proximal and then the distal action potentials at both threshold and suprathreshold levels of stimulation. This progressive blockade of proximal and distal voltage-dependent sodium channels suggests that sodium action potentials can be generated in the distal apical dendrites of CA1 pyramidal cells.
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页码：73 / 76
页数：4
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