POOR CLINICAL OUTCOME OF PATIENTS DEVELOPING MALIGNANT SOLID TUMORS AFTER BONE-MARROW TRANSPLANTATION FOR SEVERE APLASTIC-ANEMIA

被引：21
作者：
SOCIE, G
HENRYAMAR, M
DEVERGIE, A
WIBAULT, P
NEIGER, M
COSSET, JM
GLUCKMAN, E
机构：
[1] Bone Marrow Transplant Unit, Hôpital Saint Louis, Paris
[2] Department of Biostatistics and Epidemiology, Institut Gustave Roussy, Villejuif
[3] Department of Radiotherapy, Institut Gustave Roussy, Villejuif
[4] Universitätsklinik für Hals Nasen und Ohrenleiden, Inselspital Bern
来源：
LEUKEMIA & LYMPHOMA | 1992年 / 7卷 / 5-6期
关键词：
APLASTIC ANEMIA; BONE MARROW TRANSPLANTATION; MALIGNANT TUMORS;
D O I：
10.3109/10428199209049797
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
From January 1974 to September 1991, 245 consecutive patients with severe aplastic anemia underwent bone marrow transplantation at the Hopital Saint-Louis, Paris, France. Five cases of solid tumor were observed overall, a number that leads to an 8-year cumulative incidence rate of 7.7% (95% CL: 0.9%, 14.5%). Relative to the general population, the risk was equal to 22 (95% CL: 7, 51; p < 0.001). The present report focuses on the unusual clinical course of patients developing malignant tumors after bone marrow transplantation for severe aplastic anemia. It also aims at reporting the difficulty encountered in comparing data from different sources.
引用
收藏
页码：419 / 423
页数：5
相关论文
共 24 条
  • [1] Thomas E.D., Frontiers in bone marrow transplantation, Blood Cells, 17, pp. 259-267, (1991)
  • [2] Champlin R.E., Treatment of Aplastic anemia: Bone marrow transplantation, immunomodulatory therapy and hematopoietic factors, Treatment of Aplastic anemia: Bone marrow transplantation, immunomodulatory therapy and hematopoietic factors, pp. 121-123, (1990)
  • [3] Gluckman E., Bone marrow transplantation for Fanconi anemia, Bone marrow transplantation for Fanconi anemia, pp. 134-144, (1990)
  • [4] Deeg H.J., Delayed complications and long term effects after bone marrow transplantation, Delayed complications and long term effects after bone marrow transplantation, pp. 641-657, (1990)
  • [5] Kolb H.J., Bender-Gotze C.H., Late complications after allogeneic bone marrow transplantation for leukemia, Bone Marrow Transplantation, 6, pp. 61-72, (1990)
  • [6] Socie G., Kolb H.J., Ljungman P., Malignant diseases after allogeneic bone marrow transplantation: The case for assessment of risk factors, British Journal of Haematology, 80, pp. 427-430, (1992)
  • [7] Socie G., Henry-Amar M., Cosset J.M., Devergie A., Girinsky E., Gluckman E., Increased incidence of solid malignant tumors after bone marrow transplantation for severe aplastic anemia, Blood, 78, pp. 277-279, (1991)
  • [8] Gluckman E., Devergie A., Dutreix J., Radio-sensitivity in Fanconi anemia, application to the conditioning regimen for bone marrow transplantation, British Journal of Haematology, 54, pp. 431-440, (1983)
  • [9] Gluckman E., Socie G., Devergie A., Bourdeau-Esperou H., Traineau R., Cosset J.M., Bone marrow transplantation in 107 patients with severe aplastic anemia using cyclophosphamide and thoraco-abdominal irradiation for conditioning: Long term follow-up, Blood, 78, pp. 2451-2455, (1991)
  • [10] Storb R., Weiden P.L., Sullivan K.M., Appelbaum F.R., Beatty P., Buckner D., Clift R.A., Doney K.C., Hansen J., Martin P.J., Sanders J.E., Stewart P., Witherspoon R.P., Thomas E.D., Second marrow transplants in patients with aplastic anemia rejecting the first graft: Use of a conditioning regimen including cyclophosphamide and anti-thymocyte globulin, Blood, 70, pp. 116-121, (1987)
123