CHROMOSOME-TRANSLOCATION AND C-MYC ACTIVATION BY EPSTEIN-BARR-VIRUS AND EUPHORBIA-TIRUCALLI IN LYMPHOCYTES-B

被引：27

作者：

AYA, T

KINOSHITA, T

IMAI, S

KOIZUMI, S

MIZUNO, F

OSATO, T

SATOH, C

OIKAWA, T

KUZUMAKI, N

OHIGASHI, H

KOSHIMIZU, K

机构：

[1] HOKKAIDO UNIV, SCH MED, INST CANC, DEPT VIROL, SAPPORO, HOKKAIDO 060, JAPAN

[2] KYOTO UNIV, FAC AGR, DEPT FOOD SCI & TECHNOL, KYOTO 606, JAPAN

[3] HOKKAIDO UNIV, SCH MED, INST CANC, MOLEC GENET LAB, SAPPORO, HOKKAIDO 060, JAPAN

来源：

LANCET | 1991年 / 337卷 / 8751期

关键词：

D O I：

10.1016/0140-6736(91)92861-U

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Dual exposure to Epstein-Barr virus and purified 4-deoxyphorbol ester derived from the plant Euphorbia tirucalli induced a high frequency of chromosomal rearrangements in human B lymphocytes in vitro. Rearrangements most commonly affected chromosome 8, the chromosome most often showing structural changes in Burkitt's lymphoma (BL) cells. E tirucalli is indigenous in parts of Africa where BL is endemic and may be an important risk factor for the disease.

引用

页码：1190 / 1190

页数：1