BLOOD-RETINA BARRIER PERMEABILITY IN DIABETES DURING ACUTE ACE-INHIBITION

被引：0

作者：

ENGLER, CB ^{[1
]}

PARVING, HH ^{[1
]}

MATHIESEN, ER ^{[1
]}

LARSEN, M ^{[1
]}

LUNDANDERSEN, H ^{[1
]}

机构：

[1] HVIDOVRE UNIV HOSP,KLAMPENBORG,DENMARK

来源：

ACTA OPHTHALMOLOGICA | 1991年 / 69卷 / 05期

关键词：

BLOOD-RETINA BARRIER; FLUOROMETRY; DIABETES-MELLITUS; HYPERTENSION; CAPTOPRIL;

D O I：

暂无

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

We assessed the acute effect of ACE-inhibition (captopril) on blood-retina barrier (BRB) permeability in 10 hypertensive insulin-dependent diabetic patients with background retinopathy in a double-masked placebo controlled cross-over study. All patients underwent ophthalmological examination, fundus photography, fluorescein angiography, vitreous fluorometry, and continuous blood pressure recording within 3 h of the drug/placebo administration. The decrease in mean arterial blood pressure, from placebo treatment 149/92 +/- 17/7 to captopril treatment 132/83 +/- 14/7 mmHg (mean +/- SD), P < 0.01 was not accompanied by a significant decrease in BRB permeability, which was 2.51 (1.24-9.15) with placebo and 3.02 (1.25-13.93).10(-7) cm/s during captopril treatment (geometric mean and range), NS. Our study suggests that abnormal leakage through the BRB in hypertensive insulin-dependent diabetic patients with background retinopathy is caused predominantly by structural changes in the retinal vessels whereas hydrostatic forces play a minor role.

引用

页码：581 / 585

页数：5

共 20 条

[1] POSTERIOR VITREOUS FLUOROPHOTOMETRY .1. DESCRIPTION OF A NEW ANALYSIS PROCEDURE AND RESULTS IN NORMAL SUBJECTS [J].