CYCLO(HIS-PRO) A METABOLITE OF THYROTROPIN-RELEASING-HORMONE - SPECIFIC BINDING TO RAT-LIVER MEMBRANES

被引:20
|
作者
MORI, M
YAMADA, M
YAMAGUCHI, M
SUZUKI, M
OHSHIMA, K
KOBAYASHI, I
KOBAYASHI, S
机构
关键词
D O I
10.1016/0006-291X(86)90583-8
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
[3H]cyclo(His-Pro) bound with high affinity (59 nM) to a single class of sites in rat liver plasma membranes, without significant tracer degradation during equilibration for 60 min at 0.degree. C. Binding was specific and saturable (3.9 pmol/mg protein), and were increased by the addition of K+, Mg++ and Na+ at optimal concentrations, but not of Ca++ at all concentrations tested. In vivo administration of cyclo(His-Pro), but not thyrotropin-releasing hormone, to rats caused the downregulation of cyclo(His-Pro)-binding sites with decreases in specific binding numbers but did not change binding activity.
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页码:443 / 451
页数:9
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