SKIN PIGMENTATION FROM CLOFAZIMINE THERAPY IN LEPROSY PATIENTS - A REAPPRAISAL

被引：47
作者：
JOB, CK
YODER, L
JACOBSON, RR
HASTINGS, RC
机构：
[1] Carville, Louisiana
来源：
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY | 1990年 / 23卷 / 02期
关键词：
D O I：
10.1016/0190-9622(90)70204-U
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Skin biopsy specimens from two lepromatous leprosy patients with dark brown pigmentation who were receiving long-term clofazimine therapy were studied. Ceroid-lipofuscin pigment was demonstrated inside macrophages that contained numerous phagolysosomes. These contained lipids and clofazimine that appeared as electron-lucent vacuoles and a lipofuscin pigment that was electron dense, granular, and lamellated. Although the presence of the drug in tissues contributed to the skin pigmentation, the main cause was a drug-induced, reversible ceroid lipofuscinosis. © 1990, American Academy of Dermatology, Inc.. All rights reserved.
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页码：236 / 241
页数：6
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