CLONING AND HETEROSPECIFIC EXPRESSION OF THE RESISTANCE DETERMINANT-VANA ENCODING HIGH-LEVEL RESISTANCE TO GLYCOPEPTIDES IN ENTEROCOCCUS-FAECIUM BM4147

被引：54

作者：

BRISSONNOEL, A ^{[1
]}

DUTKAMALEN, S ^{[1
]}

MOLINAS, C ^{[1
]}

LECLERCQ, R ^{[1
]}

COURVALIN, P ^{[1
]}

机构：

[1] UNIV PARIS 12,HOP HENRI MONDOR,SERV BACTERIOL VIROL HYG,F-94010 CRETEIL,FRANCE

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1990年 / 34卷 / 05期

关键词：

D O I：

10.1128/AAC.34.5.924

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Fragments of plasmid pIP816, which confers high-level glycopeptide resistance in Enterococcus faecium BM4147, were cloned into a conjugative gram-negative-gram-positive shuttle vector. The resulting hybrids were transferred by conjugation from Escherichia coli to Enterococcus faecalis and Bacillus thuringiensis. A 4-kilobase EcoRI fragment from pIP816 was found to confer vancomycin resistance in these hosts but not in E. coli or Bacillus subtilis.

引用

页码：924 / 927

页数：4

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