ALTERATIONS OF LOW-MOLECULAR-WEIGHT ACID-PHOSPHATASE PROTEIN LEVEL IN ALZHEIMERS-DISEASE

被引：11

作者：

SHIMOHAMA, S

FUJIMOTO, S

CHACHIN, M

TANIGUCHI, T

PERRY, G

WHITEHOUSE, PJ

KIMURA, J

机构：

[1] KYOTO PHARMACEUT UNIV,DEPT BIOCHEM,KYOTO 607,JAPAN

[2] KYOTO PHARMACEUT UNIV,DEPT NEUROBIOL,KYOTO 607,JAPAN

[3] CASE WESTERN RESERVE UNIV,INST PATHOL,CLEVELAND,OH 44106

[4] CASE WESTERN RESERVE UNIV,DEPT NEUROL,CLEVELAND,OH 44106

来源：

BRAIN RESEARCH | 1995年 / 699卷 / 01期

关键词：

ACID PHOSPHATASE; LOW MOLECULAR WEIGHT; ANTIBODY; PROTEIN LEVEL; ACTIVITY; ALZHEIMERS DISEASE;

D O I：

10.1016/0006-8993(95)00995-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We have previously reported that the activity of low molecular weight (LMW) acid phosphatase, which can remove tyrosine-linked phosphates of epidermal growth factor receptor, was significantly decreased in Alzheimer brains. In the present study, a specific antibody was prepared to analyze the protein lever of this enzyme. Western blot analysis indicated that the level of LMW acid phosphatase protein was significantly reduced, whereas the activity of LMW acid phosphatase per enzyme molecule was not changed in Alzheimer brains. These results suggest that the reduction of LMW acid phosphatase activity in Alzheimer brains is due to its decreased protein level in Alzheimer's disease.

引用

页码：125 / 129

页数：5

共 13 条

[11] REDUCTION OF LOW-MOLECULAR-WEIGHT ACID-PHOSPHATASE-ACTIVITY IN ALZHEIMER BRAINS
SHIMOHAMA, S
FUJIMOTO, S
TANIGUCHI, T
KAMEYAMA, M
KIMURA, J
[J]. ANNALS OF NEUROLOGY, 1993, 33 (06) : 616 - 621
[12] THE ENDOGENOUS SUBSTRATE OF LOW-MOLECULAR-WEIGHT ACID-PHOSPHATASE IN THE BRAIN IS AN EPIDERMAL GROWTH-FACTOR RECEPTOR
SHIMOHAMA, S
FUJIMOTO, S
TANIGUCHI, T
KIMURA, J
[J]. BRAIN RESEARCH, 1994, 662 (1-2) : 185 - 188
[13] TYROSINE PHOSPHORYLATION SYSTEMS IN ALZHEIMERS-DISEASE PATHOLOGY
WOOD, JG
ZINSMEISTER, P
[J]. NEUROSCIENCE LETTERS, 1991, 121 (1-2) : 12 - 16

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