TAXANES - A NEW CLASS OF ANTITUMOR AGENTS

被引：244

作者：

HUIZING, MT

MISSER, VHS

PIETERS, RC

HUININK, WWT

VEENHOF, CHN

VERMORKEN, JB

PINEDO, HM

BEIJNEN, JH

机构：

[1] SLOTERVAART HOSP,DEPT PHARM,1066 EC AMSTERDAM,NETHERLANDS

[2] NETHERLANDS CANC INST,DEPT MED ONCOL,1066 CX AMSTERDAM,NETHERLANDS

[3] UNIV AMSTERDAM,ACAD MED CTR,DEPT MED ONCOL,1105 AZ AMSTERDAM,NETHERLANDS

[4] FREE UNIV AMSTERDAM HOSP,DEPT MED ONCOL,1081 HV AMSTERDAM,NETHERLANDS

来源：

CANCER INVESTIGATION | 1995年 / 13卷 / 04期

关键词：

D O I：

10.3109/07357909509031919

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Taxanes belong to a new group of antineoplastic agents with a novel mechanism of action for a cytotoxic drug. They promote microtubule assembly and stabilize the microtubules. Paclitaxel, the first agent in this group to become available, was isolated from the Pacific yew, Taxus brevifolia, in 1971. In preclinical and clinical studies, paclitaxel and its semisynthetic analog docetaxel exhibit significant antitumor activity. This review deals with the physicochemical properties, pharmacology, and results of preclinical and clinical trials of the taxanes.

引用

页码：381 / 404

页数：24

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