CANNABINOIDS ENHANCE HUMAN B-CELL GROWTH AT LOW NANOMOLAR CONCENTRATIONS

被引：149
作者：
DEROCQ, JM
SEGUI, M
MARCHAND, J
LEFUR, G
CASELLAS, P
机构：
[1] Department of Immunology, Sanofi Recherche
来源：
FEBS LETTERS | 1995年 / 369卷 / 2-3期
关键词：
CANNABINOID; IMMUNOMODULATION; B-CELL ACTIVATION; CP55,940; TRIANGLE-9-TETRAHYDROCANNABINOL; WIN55212-2;
D O I：
10.1016/0014-5793(95)00746-V
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
This study examined the effect of cannabinoid ligands on human tonsillar B-cells activated either through cross-linking of surface immunoglobulins or ligation of the CD40 antigen. The two synthetic cannabinoids, CP55,940 and WIN55212-2, as well as Delta(9)-tetrahydrocannabinol (THC), the psychoactive component of marijuana, caused a dose-dependent increase of B-cell proliferation and displayed EC(50) at low nanomolar concentrations. This cannabinoid-induced enhancing activity mas inhibited by pertussis toxin which suggested a G-protein-coupled receptor process. In addition, the absence of antagonistic effect of SR141716A, a specific CB1 receptor antagonist, together with the demonstration that human B-cells displayed large amount of CB2 receptor mRNAs, led us to assume that the growth enhancing activity observed on B-cells at very low concentrations of cannabinoids could be mediated through the CB2 receptor.
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收藏
页码：177 / 182
页数：6
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