PRIMARY SCLEROSING CHOLANGITIS (PSC) AND TAMOXIFEN

被引：2

作者：

SCAPA, E ^{[1
]}

ORDA, R ^{[1
]}

机构：

[1] TEL AVIV UNIV,SACKLER FAC MED,ASSAF HAROFEH MED CTR,DEPT SURG A,IL-69978 TEL AVIV,ISRAEL

来源：

INTERNATIONAL HEPATOLOGY COMMUNICATIONS | 1995年 / 4卷 / 03期

关键词：

PRIMARY SCLEROSING CHOLANGITIS; TAMOXIFEN;

D O I：

10.1016/0928-4346(95)00239-1

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

There is no effective medical treatment for primary sclerosing cholangitis (PSC). Tamoxifen was found to have anti-fibrotic properties and has only few and rare side-effects. We gave 6 PSC patients 20 mg/day of tamoxifen and we studied its influence on the alkaline phosphatase (ALP) serum levels, Duration of treatment was from 1 to 8 months. Two patients showed a decline of their ALP to normal values, the other 4 patients showed improvement. Our results are encouraging and a larger scale study for a longer period of time is needed to evaluate the effect of tamoxifen on PSC patients, In such a study, liver biopsies should be performed for histological evaluation.

引用

页码：149 / 152

页数：4

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