PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE (PACAP) STIMULATES MELATONIN SYNTHESIS FROM RAT PINEAL-GLAND

被引：74
作者：
SIMONNEAUX, V
OUICHOU, A
PEVET, P
机构：
[1] Neurobiologie des Fonctions Rythmiques et Saisonnières, URA-CNRS 1332, Université Louis Pasteur, Strasbourg
来源：
BRAIN RESEARCH | 1993年 / 603卷 / 01期
关键词：
PITUITARY ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE; VASOACTIVE INTESTINAL POLYPEPTIDE; MELATONIN; PINEAL GLAND; CELL CULTURE; RAT;
D O I：
10.1016/0006-8993(93)91313-H
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The effect of pituitary adenylate cyclase polypeptide (PACAP) on rat pineal was examined. PACAP stimulated melatonin release from cultured dissociated pinealocytes with a 10(4) higher potency than isoproterenol (EC50 were 30 pM and 250 nM, respectively). The 10(-9)) M PACAP stimulation was not inhibited by 5 x 10(-6) M VIP antagonist whereas that of 10(-9) M VIP was reduced by 54%. Kinetic analysis of melatonin release indicated that PACAP acts postsynaptically via receptor activation.
引用
收藏
页码：148 / 152
页数：5
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