DESIGN OF POTENT, ORALLY EFFECTIVE, NONPEPTIDAL ANTAGONISTS OF THE PEPTIDE-HORMONE CHOLECYSTOKININ

被引:395
作者
EVANS, BE
BOCK, MG
RITTLE, KE
DIPARDO, RM
WHITTER, WL
VEBER, DF
ANDERSON, PS
FREIDINGER, RM
机构
关键词
D O I
10.1073/pnas.83.13.4918
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
引用
收藏
页码:4918 / 4922
页数:5
相关论文
共 42 条
[1]  
ALBERSSCHONBERG G, 1985, 9TH P AM PEPT S, P565
[2]   DIAZEPAM-BINDING INHIBITOR - A NEUROPEPTIDE LOCATED IN SELECTED NEURONAL POPULATIONS OF RAT-BRAIN [J].
ALHO, H ;
COSTA, E ;
FERRERO, P ;
FUJIMOTO, M ;
COSENZAMURPHY, D ;
GUIDOTTI, A .
SCIENCE, 1985, 229 (4709) :179-182
[3]   CHOLECYSTOKININ IN THE CENTRAL NERVOUS-SYSTEM - A MINIREVIEW [J].
BEINFELD, MC .
NEUROPEPTIDES, 1983, 3 (06) :411-427
[4]   A NEW SYNTHESIS OF 7-CHLORO-1,3-DIHYDRO-5-PHENYL-2H-1,4-BENZODIAZEPIN-2-ONE 4-OXIDE [J].
BELL, SC ;
MCCAULLY, RJ ;
CHILDRES.SJ .
JOURNAL OF HETEROCYCLIC CHEMISTRY, 1967, 4 (04) :647-&
[5]   3-SUBSTITUTED 1,4-BENZODIAZEPIN-2-ONES [J].
BELL, SC ;
MCCAULLY, RJ ;
GOCHMAN, C ;
CHILDRESS, SJ ;
GLUCKMAN, MI .
JOURNAL OF MEDICINAL CHEMISTRY, 1968, 11 (03) :457-+
[6]   A REARRANGEMENT OF 5-ARYL-1,3-DIHYDRO-2H-1,4-BENZODIAZEPINE-2-14-OXIDES [J].
BELL, SC ;
CHILDRESS, SJ .
JOURNAL OF ORGANIC CHEMISTRY, 1962, 27 (05) :1691-&
[7]  
BELL SC, 1965, Patent No. 3198789
[8]  
BOCK MG, 1986, J MED CHEM
[9]   BENZODIAZEPINES ANTAGONIZE CHOLECYSTOKININ-INDUCED ACTIVATION OF RAT HIPPOCAMPAL-NEURONS [J].
BRADWEJN, J ;
DEMONTIGNY, C .
NATURE, 1984, 312 (5992) :363-364
[10]   ANTAGONISM OF CHOLECYSTOKININ-INDUCED ACTIVATION BY BENZODIAZEPINE RECEPTOR AGONISTS - MICROIONTOPHORETIC STUDIES IN THE RAT HIPPOCAMPUS [J].
BRADWEJN, J ;
DEMONTIGNY, C .
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1985, 448 (JUL) :575-580