SUSTAINED-RELEASE FORMULATION OF SALBUTAMOL SULFATE

被引：4
|
作者：
MURTHY, RSR [1 ]
MALHOTRA, M [1 ]
MIGLANI, BD [1 ]
机构：
[1] COLL PHARM,NEW DELHI 17,INDIA
来源：
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY | 1991年 / 17卷 / 10期
关键词：
D O I：
10.3109/03639049109057302
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Sustained release tablets containing salbutamol sulphate has been prepared by wax matrix granulation method and were evaluated for in vitro release profile and in vivo availability studies in dogs. Out of the release retarding waxy materials used combinations of carnauba wax and stearyl alcohol in concentration range between 60 to 70% of the weight of the tablet were found to be optimum in fabricating sustained release tablets for twenty-four hours duration of action. The formulations were also compared with marketed products of salbutamol for in vitro release profile.
引用
收藏
页码：1373 / 1380
页数：8
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