PROOPIOMELANOCORTIN EXPRESSION IN THE SKIN DURING INDUCED HAIR-GROWTH IN MICE

被引：104

作者：

SLOMINSKI, A

PAUS, R

MAZURKIEWICZ, J

机构：

[1] ALBANY MED COLL,DEPT ANAT CELL BIOL & NEUROBIOL,ALBANY,NY 12202

[2] FREE UNIV BERLIN,HOSP R VIRCHOW,DEPT DERMATOL,W-1000 BERLIN 65,GERMANY

来源：

EXPERIENTIA | 1992年 / 48卷 / 01期

关键词：

PROOPIOMELANOCORTIN; HAIR GROWTH; SKIN; C57B1; 6; MICE; BETA-ENDORPHIN;

D O I：

10.1007/BF01923606

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We demonstrate for the first time a hair cycle-dependent gene and protein expression of proopiomelanocortin in mouse skin in vivo. Northern blot detected POMC mRNA with an apparent size of 0.9 kb in anagen but not telogen skin. Western blot emphasized a specific protein of 30-33 kDa recognized by anti beta-endorphin in late but not early anagen or telogen skin. By immunocytochemistry, beta-endorphin antigen was localized in the sebaceous gland in a hair cycle dependent manner.

引用

页码：50 / 54

页数：5

共 20 条

[1] THE DISTRIBUTION OF FORMS OF ADRENOCORTICOTROPIN AND BETA-ENDORPHIN IN NORMAL, TUMOROUS, AND AUTOPSY HUMAN ANTERIOR-PITUITARY TISSUE - VIRTUAL ABSENCE OF 13K-ADRENOCORTICOTROPIN [J].