Advances of active ingredients of traditional Chinese medicine in the prevention and treatment of osteoarthritis

被引：1

作者：

Han Han ^{[1
,2
]}

Zhang Yuanyuan ^{[1
,2
]}

Pan Li ^{[1
,2
]}

Chen Zhengdong ^{[1
,2
]}

Xue Lixuan ^{[1
,2
]}

Yu Boyang ^{[1
,2
]}

Kou Jun-Ping ^{[1
,2
]}

机构：

[1] China Pharmaceut Univ, Jiangsu Key Lab Tradit Chinese Med Evaluat & Tran, Nanjing 211198, Jiangsu, Peoples R China

[2] China Pharmaceut Univ, Sch Tradit Chinese Pharm, Nanjing 211198, Jiangsu, Peoples R China

来源：

JOURNAL OF CHINA PHARMACEUTICAL UNIVERSITY | 2018年 / 49卷 / 03期

关键词：

Active ingredients; Mechanism; Osteoarthritis; Traditional Chinese medicine;

D O I：

10.11665/j.issn.1000-5048.20180304

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Osteoarthritis (OA), a common chronic degenerative joint disease, rises gradually with age, which seriously affects the quality of life of middle-aged and elderly patients. Currently, the therapeutic medications such as nonsteroidal anti-inflammatory drugs (NSAIDs) and analgesics might improve OA symptoms, but cannot prevent the development of OA. The active ingredients of traditional Chinese medicine (TCM) have unique advantages in the treatment of OA. This article reviews the research progress of active ingredients of TCM in the prevention and treatment of OA reported by domestic and foreign journals in the past five years from the aspects of inhibition of the secretion of inflammation-related factors, improvement of cartilage matrix synthesis and catabolic imbalance, inhibition of chondrocyte apoptosis, promotion of chondrocyte proliferation, and regulation of estrogen levels, with an attempt to provide a theoretical basis for the development of new drugs for OA.

引用

页码：279 / 285

页数：7

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