ADENOVIRUS-TRIGGERED INNATE SIGNALLING PATHWAYS

被引：32

作者：

Fejer, G. ^{[1
,2
]}

Freudenberg, M. ^{[1
]}

Greber, U. F. ^{[3
]}

Gyory, I. ^{[1
]}

机构：

[1] Max Planck Inst Immunobiol & Epigenet, Stubeweg 51, D-79108 Freiburg, Germany

[2] Peninsula Coll Med & Dent, Plymouth, Devon, England

[3] Univ Zurich, Inst Mol Life Sci, Zurich, Switzerland

来源：

EUROPEAN JOURNAL OF MICROBIOLOGY AND IMMUNOLOGY | 2011年 / 1卷 / 04期

关键词：

adenovirus; viral entry; endosomal escape; innate response; Toll-like receptors; type-I interferons; IL-1; IRF7;

D O I：

10.1556/EuJMI.1.2011.4.3

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Adenoviruses are important infectious agents and also emerging vectors in different biomedical applications. These viruses elicit a strong innate and adaptive immune response, which influences both the course of disease and the success of the applied vectors. Several Toll-like Receptor (TLR)-dependent and -independent mechanisms contribute to these responses. Understanding of the involved viral and cellular factors is crucial for the treatment of various adenovirus diseases and the optimal design of adenovirus vector applications. Here we summarize our current understanding of the complex nature of adenovirus-induced innate immune mechanisms.

引用

页码：279 / 288

页数：10

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