EFFECTS OF DIRECT PERCUTANEOUS TRANSLUMINAL CORONARY ANGIOPLASTY TREATMENT OF ACUTE MYOCARDIAL-INFARCTION ON PLASMA-LEVELS OF HEMOSTATIC AND FIBRINOLYTIC FACTORS

被引：0

作者：

SAITO, M ^{[1
]}

NAKABAYASHI, T ^{[1
]}

IUCHI, K ^{[1
]}

ISHIKAWA, T ^{[1
]}

KASENO, K ^{[1
]}

YOSHIDA, T ^{[1
]}

ASAKURA, H ^{[1
]}

MATSUDA, T ^{[1
]}

机构：

[1] TOYAMA PREFECTURAL CENT HOSP,TOYAMA,JAPAN

来源：

BLOOD COAGULATION & FIBRINOLYSIS | 1993年 / 4卷 / 05期

关键词：

ACUTE MYOCARDIAL INFARCTION; DIRECT PERCUTANEOUS TRANSLUMINAL CORONARY ANGIOPLASTY; THROMBIN-ANTITHROMBIN-III COMPLEX; PLASMINOGEN ACTIVATOR INHIBITOR-1;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Although thrombolytic therapy is used widely for treatment of acute myocardial infarction (AMI), thrombolysis itself increases thrombin activity and may cause reocclusion of infarct-related vessels. Direct percutaneous transluminal coronary angioplasty (PTCA) is an effective treatment for AMI; however, it is not clear what effects PTCA has on coagulation and fibrinolysis. We investigated coagulation and fibrinolytic factor concentrations before and after direct PTCA. Plasma levels of thrombin-antithrombin III complex (TAT), D-dimer, plasmin-(alpha2-antiplasmin complex (PAP), tissue-type plasminogen activator (t-PA) antigen and plasminogen activator inhibitor (PAI)-1 antigen were followed in twelve patients treated with direct PTCA for AMI. Before PTCA, only TAT concentrations were significantly elevated compared to normal controls. D-dimer, TAT, PAP and PAI-1 concentrations were similar before and after PTCA. Eleven patients had no recurrent ischaemia and no restenosis on follow-up coronary angiography. These data confirm that direct PTCA is less likely than thrombolysis to affect coagulation and fibrinolysis.

引用

页码：801 / 804

页数：4

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