INHALATION PHARMACOKINETICS - EVALUATING SYSTEMIC EXTRACTION, TOTAL INVIVO METABOLISM, AND THE TIME COURSE OF ENZYME-INDUCTION FOR INHALED STYRENE IN RATS BASED ON ARTERIAL BLOOD - INHALED AIR CONCENTRATION RATIOS

被引：54

作者：

ANDERSEN, ME ^{[1
]}

GARGAS, ML ^{[1
]}

RAMSEY, JC ^{[1
]}

机构：

[1] DOW CHEM USA,TOXICOL RES LAB,MIDLAND,MI 48640

来源：

TOXICOLOGY AND APPLIED PHARMACOLOGY | 1984年 / 73卷 / 01期

关键词：

D O I：

10.1016/0041-008X(84)90065-6

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

引用

页码：176 / 187

页数：12

共 19 条

[1]

ANDERSEN ME, 1981, NEUROBEH TOXICOL TER, V3, P383

[2] USE OF INHALATION TECHNIQUES TO ASSESS THE KINETIC CONSTANTS OF 1,1-DICHLOROETHYLENE METABOLISM [J].

ANDERSEN, ME ;

GARGAS, ML ;

JONES, RA ;

JENKINS, LJ .

TOXICOLOGY AND APPLIED PHARMACOLOGY, 1979, 47 (02) :395-409

[3] DETERMINATION OF THE KINETIC CONSTANTS FOR METABOLISM OF INHALED TOXICANTS INVIVO USING GAS UPTAKE MEASUREMENTS [J].

ANDERSEN, ME ;

GARGAS, ML ;

JONES, RA ;

JENKINS, LJ .

TOXICOLOGY AND APPLIED PHARMACOLOGY, 1980, 54 (01) :100-116

[4] RECENT ADVANCES IN METHODOLOGY AND CONCEPTS FOR CHARACTERIZING INHALATION PHARMACOKINETIC PARAMETERS IN ANIMALS AND MAN [J].

ANDERSEN, ME .

DRUG METABOLISM REVIEWS, 1982, 13 (05) :799-826

[5] A PHYSIOLOGICALLY BASED TOXICOKINETIC DESCRIPTION OF THE METABOLISM OF INHALED GASES AND VAPORS - ANALYSIS AT STEADY-STATE [J].

ANDERSEN, ME .

TOXICOLOGY AND APPLIED PHARMACOLOGY, 1981, 60 (03) :509-526

[6] METHOTREXATE PHARMACOKINETICS [J].

BISCHOFF, KB ;

DEDRICK, RL ;

ZAHARKO, DS ;

LONGSTRETH, JA .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1971, 60 (08) :1128-+

[7] METABOLISM OF INHALED BROMINATED HYDROCARBONS - VALIDATION OF GAS UPTAKE RESULTS BY DETERMINATION OF A STABLE METABOLITE [J].

GARGAS, ML ;

ANDERSEN, ME .

TOXICOLOGY AND APPLIED PHARMACOLOGY, 1982, 66 (01) :55-68

[8]

Hilderbrand R L, 1981, Fundam Appl Toxicol, V1, P403, DOI 10.1016/S0272-0590(81)80017-6

[9] REVIEW OF THE APPLICATIONS OF PHYSIOLOGICALLY BASED PHARMACOKINETIC MODELING [J].

HIMMELSTEIN, KJ ;

LUTZ, RJ .

JOURNAL OF PHARMACOKINETICS AND BIOPHARMACEUTICS, 1979, 7 (02) :127-145

[10]

KARBOWSKI RJ, 1980, 19TH ANN M SOC TOX W

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