RESPONSES OF SUBSTANTIA-NIGRA PARS RETICULATA AND GLOBUS-PALLIDUS COMPLEX TO HIGH-FREQUENCY STIMULATION OF THE SUBTHALAMIC NUCLEUS IN RATS - ELECTROPHYSIOLOGICAL DATA

被引：287
作者：
BENAZZOUZ, A
PIALLAT, B
POLLAK, P
BENABID, AL
机构：
[1] Laboratoire de Neurobiophysique, UJFG, INSERM U.318, 38043 Grenoble cedex
来源：
NEUROSCIENCE LETTERS | 1995年 / 189卷 / 02期
关键词：
EXTRACELLULAR RECORDING; HIGH FREQUENCY STIMULATION; SUBTHALAMIC NUCLEUS; SUBSTANTIA NIGRA; ENTOPEDUNCULAR NUCLEUS; RATS;
D O I：
10.1016/0304-3940(95)11455-6
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
High frequency stimulation of the subthalamic nucleus (STN-HFS) has been shown to reverse parkinsonian motor symptoms in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated monkeys. We have studied the effect of STN-HFS on the spontaneous activity of the substantia nigra pars reticulata (SNr), entopeduncular nucleus (EP) and globus pallidus (GP) in rats. STN-HFS induced a decrease in activity of 91% of SN; cells, a suppression of activity in 80% of EP cells and an activation of 100% of GP recorded cells. These results show that STN-HFS exerts an inhibitory influence on the basal ganglia output structures similar to that obtained by STN lesion.
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页码：77 / 80
页数：4
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