THE ROLE OF ARGININE-VASOPRESSIN IN INTERLEUKIN-1-BETA-INDUCED ADRENOCORTICOTROPIN SECRETION IN THE RAT

被引：9
作者：
SASAKI, S
WATANOBE, H
TAKEBE, K
机构：
[1] Third Department oflntemal Medicine, Hirosaki University, School of Medicine, Hirosaki
来源：
NEUROIMMUNOMODULATION | 1995年 / 2卷 / 03期
关键词：
INTERLEUKIN-1-BETA; ADRENOCORTICOTROPIN; CORTICOTROPIN-RELEASING HORMONE; ARGININE VASOPRESSIN; IMMUNONEUTRALIZATION;
D O I：
10.1159/000096882
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
In this study we examined whether arginine vasopressin (AVP) in the brain is involved in the adrenocorticotropin (ACTH) secretion induced by interleukin (IL)-1 beta in the rat. Human recombinant IL-1 beta (50 ng) was given intracerebroventricularly to freely moving male rats with or without a prior (15 min before) administration of anticorticotropin releasing hormone (CRH) or AVP antibody via the same route. The ACTH response to IL-1 beta was significantly reduced by both anti-CRH and anti-AVP antisera compared to the levels after normal rabbit serum. These results suggest that not only CRH but also AVP may mediate the IL-1 beta stimulation of ACTH secretion in the rat.
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收藏
页码：134 / 136
页数：3
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