ACUTE AND LONG-TERM GENOTOXIC EFFECTS OF CDCL2 ON TESTES OF MICE

被引：24
|
作者：
SELYPES, A [1 ]
SERENYI, P [1 ]
BOLDOG, I [1 ]
BOKROS, F [1 ]
TAKACS, S [1 ]
机构：
[1] J HOLLOS HOSP,DEPT PATHOL,KECSKEMET,HUNGARY
来源：
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH | 1992年 / 36卷 / 04期
关键词：
D O I：
10.1080/15287399209531647
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
The effects of Cd administered ip in a single carcinogenic dose (1 mg Cd/kg body weight) into male CFLP mice were investigated on the histological and cytogenetic status of the testes of the animals on d 3 and 6 mo after the Cd injection. There were some characteristic histological changes in the testes of the mice on d 3 after Cd treatment. the presence of interstitial hemorrhages, the death of Leydig cells, sterile necroses of tubular elements, and numerous atypical mitoses of the spermatocytes. A significant increase compared with the control was found only in the number of numerical chromosome aberrations in the Cd-treated group. Six months later a significant difference compared with the control was found only in the relative weight of the testes in the treated group. There were soon no detectable effects of Cd on the histological picture of the testes and on the spermatocytes.
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页码：401 / 409
页数：9
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